The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea
Salicylate poisoning is a classic cause of metabolic acidosis with anion gap. Anion gap may be masked by the false reading of salicylate as chloride ion by some analyzers (PMID 21492961, 23867355)
Publications
Salicylate-induced pulmonary edema--a near-miss diagnosis.
The American journal of emergency medicine. 2014;32(5):490.e5-6
Negative anion gap metabolic acidosis in salicylate overdose--a zebra!
The American journal of emergency medicine. 2013;31(10):1536.e3-4
Falsely normal anion gap in severe salicylate poisoning caused by laboratory interference.
Annals of emergency medicine. 2011;58(3):280-1
Hospital-acquired salicylate intoxication. report of a case with psychosis, acidosis, and coma.
The Journal of rheumatology. 1975;2(1):52-60