The Drug-Induced Respiratory Disease Website and App

Propylthiouracil (PTU)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I - Interstitial/parenchymal lung disease

I.a

Pneumonitis (interstitial lung disease/ILD)

I.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

I.e

Organizing pneumonia pattern (an area or areas of consolidation on imaging)

I.l

Lung nodule or nodules

XLI - Pulmonary edema - Acute lung injury - ARDS

XLI.e

ARDS - Acute lung injury

XLI.p

Acute respiratory or cardiopulmonary failure

XLII - Pulmonary/alveolar./airway hemorrhage/bleeding

XLII.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

XLII.b

Pneumorenal syndrome (w/wo ANCAs)

XLII.d

Alveolar hemorrhage, diffuse (ANCA-positive/-related)

XLIII - Airway involvement

XLIII.a

Bronchospasm - Wheezing - Asthma

XLIII.k

Airway pigmentation (black, bluish, petechial)

XLV - Pleural and/or pericardial involvement

XLV.b

Eosinophilic pleural effusion

XLV.d

Pleural/pericardial effusion, ANA positive (DI lupus)

XLV.m

Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)

XLV.v

Eosinophilic pleuritis

XLVI - Pulmonary vasculopathy

XLVI.d

Pulmonary vasculitis or capillaritis

XLIX - Systemic/Distant conditions, syndromes and reactions

XLIX.d

Lupus - Lupus syndrome (see also Vd)

XLIX.e

Autoimmunity-Autoimmune conditions (+ANA, +anti-ds-DNA, +ANCAs, other auto-Abs)

XLIX.o

Vascultis (pulmonary, extrathoracic or systemic)-ANCA status unknown or negative)

XLIX.u

Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive

XLIX.z

ANCA positivity. Subclinical or with clinical manifestations

XLIX.am

Dual MPO-/PR3-ANCA systemic disease/vasculitis/pseudovasculitis

L - Miscellaneous

L.l

Neutropenia, agranulocytosis (w/wo infection/sepsis)

LVIII - Pathology

LVIII.a

Path: NSIP-cellular pattern (see also Ia, Ib)

LVIII.d

Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)

LVIII.v

Path: NSIP-fibrotic pattern

LVIII.bn

Path: Eosinophilic pleuritis