The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

V.m

Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)

Publications

Rosen DR, Cologne KG, Popek SM, Sung BC, Ortega AE, Senagore AJ

Recurrent drug-induced ANCA vasculitis in a patient with Crohn's colitis treated with infliximab: a potential contraindication to immunosuppressive therapy.

The American surgeon. 2012;78(12):1406-8

Tetikkurt C, Yuruyen M, Tetikkurt S, Bayar N, Ozdemir I

Propylthiouracil-induced lupus-like or vasculitis syndrome.

Multidisciplinary respiratory medicine. 2012;7(1):14

Dinmezel S, Ogus C, Ozdemir T

Antineutrophil cytoplasmic antibody-positive vasculitis associated with propylthiouracil therapy.

Clinical drug investigation. 2003;23(12):817-21