The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.m

Vascultis (pulmonary, extrathoracic or systemic)-ANCA status unknown or negative)

Publications

Karageorgiou I, Pokharel A, Pokharel A, Niedzialkowska E, Bateman J

Propylthiouracil-Induced Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis Presenting with Multiple Sterile Abscesses, Mononeuritis Multiplex, and Splenic Vein Thrombosis: A Case Report and Literature Review.

Cureus. 2024;16(5):e61229

Cassorla FG, Finegold DN, Parks JS, Tenore A, Thawerani H, Baker L

Vasculitis, pulmonary cavitation, and anemia during antithyroid drug therapy.

American journal of diseases of children (1960). 1983;137(2):118-22

Houston BD, Crouch ME, Brick JE, DiBartolomeo AG

Apparent vasculitis associated with propylthiouracil use.

Arthritis and rheumatism. 1979;22(8):925-8