The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.s

Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive

Publications

Karageorgiou I, Pokharel A, Pokharel A, Niedzialkowska E, Bateman J

Propylthiouracil-Induced Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis Presenting with Multiple Sterile Abscesses, Mononeuritis Multiplex, and Splenic Vein Thrombosis: A Case Report and Literature Review.

Cureus. 2024;16(5):e61229

Arnold S, Kitching AR, Witko-Sarsat V, Wiech T, Specks U, Klapa S, Comdühr S, Stähle A, Müller A, Lamprecht P

Myeloperoxidase-specific antineutrophil cytoplasmic antibody-associated vasculitis.

The Lancet. Rheumatology. 2024;6(5):e300-e313

Okuda S, Hirooka Y, Sugiyama M

Propylthiouracil-Induced Antineutrophil Cytoplasmic Antibody-Associated Vasculitis after COVID-19 Vaccination.

Vaccines. 2021;9(8)

Lam B, Yuile A, Fernando SL

Propylthiouracil-induced vasculitis in carbimazole-refractory Graves disease.

The Medical journal of Australia. 2019;210(11):491-491.e1

Hasegawa A, Fujimoto A, Yuki D, Hayashi R, Aizawa A, Ito T, Abe R

PR3-ANCA: a potential biomarker of disease activity for propylthiouracil-induced ANCA-associated vasculitis.

European journal of dermatology : EJD. 2018;28(4):530-531

Khan TA, Yin Luk FC, Uqdah HT, Arif A, Hussain H, Jayatilleke A, Aggarwal S

A fatal case of propylthiouracil-induced ANCA-associated vasculitis resulting in rapidly progressive glomerulonephritis, acute hepatic failure, and cerebral angiitis.

Clinical nephrology. 2015;83(5):309-14

Iyoda M, Kuroki A, Kato K, Shibata T, Kitazawa K, Sugisaki T

Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis in a patient with a predisposition to autoimmune abnormalities.

Modern rheumatology. 2003;13(2):173-6

Pendergraft WF 3rd, Niles JL

Trojan horses: drug culprits associated with antineutrophil cytoplasmic autoantibody (ANCA) vasculitis.

Current opinion in rheumatology. 2014;26(1):42-9

Wang C, Gou SJ, Xu PC, Zhao MH, Chen M

Epitope analysis of anti-myeloperoxidase antibodies in propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis.

Arthritis research & therapy. 2013;15(6):R196

Ozkok A, Kaya S, Elcioglu OC, Odabas AR

Propylthiouracil-induced cryoglobulinemic vasculitis.

Internal medicine (Tokyo, Japan). 2013;52(17):2011-2

Cao X, Lin W

Clinical study of renal impairment in patients with propylthiouracil-induced small-vessel vasculitis and patients with primary ANCA-associated small-vessel vasculitis.

Experimental and therapeutic medicine. 2013;5(6):1619-1622

Rosen DR, Cologne KG, Popek SM, Sung BC, Ortega AE, Senagore AJ

Recurrent drug-induced ANCA vasculitis in a patient with Crohn's colitis treated with infliximab: a potential contraindication to immunosuppressive therapy.

The American surgeon. 2012;78(12):1406-8

Tetikkurt C, Yuruyen M, Tetikkurt S, Bayar N, Ozdemir I

Propylthiouracil-induced lupus-like or vasculitis syndrome.

Multidisciplinary respiratory medicine. 2012;7(1):14

Ahmed K, Rao S, Simha V

Antineutrophil cytoplasmic antibody-positive vasculitis in a patient with graves disease: cross-reaction between propylthiouracil and methimazole.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2010;16(3):449-51

Sangala N, Lee RW, Horsfield C, Goldsmith DJ

Combined ANCA-associated vasculitis and lupus syndrome following prolonged use of hydralazine: a timely reminder of an old foe.

International urology and nephrology. 2010;42(2):503-6

Pillinger MH, Staud R

Propylthiouracil and antineutrophil cytoplasmic antibody associated vasculitis: the detective finds a clue.

Seminars in arthritis and rheumatism. 2006;36(1):1-3

Hardy OT, Smolinski KN, Yan AC, Grimberg A

PTU-associated vasculitis in a girl with Turner Syndrome and Graves' disease.

Pediatric emergency care. 2006;22(1):52-4

Herlin T, Birkebaek NH, Wolthers OD, Heegaard NH, Wiik A

Anti-neutrophil cytoplasmic autoantibody (ANCA) profiles in propylthiouracil-induced lupus-like manifestations in monozygotic triplets with hyperthyroidism.

Scandinavian journal of rheumatology. 2002;31(1):46-9

Choi HK, Merkel PA, Walker AM, Niles JL

Drug-associated antineutrophil cytoplasmic antibody-positive vasculitis: prevalence among patients with high titers of antimyeloperoxidase antibodies.

Arthritis and rheumatism. 2000;43(2):405-13

Dhillon SS, Singh D, Doe N, Qadri AM, Ricciardi S, Schwarz MI

Diffuse alveolar hemorrhage and pulmonary capillaritis due to propylthiouracil.

Chest. 1999;116(5):1485-8

Choi HK, Merkel PA, Tervaert JW, Black RM, McCluskey RT, Niles JL

Alternating antineutrophil cytoplasmic antibody specificity: drug-induced vasculitis in a patient with Wegener's granulomatosis.

Arthritis and rheumatism. 1999;42(2):384-8

D'Cruz D, Chesser AM, Lightowler C, Comer M, Hurst MJ, Baker LR, Raine AE

Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis associated with anti-thyroid drug treatment.

British journal of rheumatology. 1995;34(11):1090-1