The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Pulmonary vasculitis or capillaritis
Publications
Epitope analysis of anti-myeloperoxidase antibodies in propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis.
Arthritis research & therapy 2013;15;R196 — 2013 — R196
Propylthiouracil-induced leucocytoclastic vasculitis with pulmonary hemorrhage treated with plasmapheresis.
The American journal of the medical sciences 2009 Jun;337;470-2 — 2009 Jun — 470-2
Clinical and pathological features of renal involvement in propylthiouracil-associated ANCA-positive vasculitis.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2007 May;49;607-14 — 2007 May — 607-14
Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune diseases induced by antithyroid drugs: comparison with idiopathic ANCA vasculitides.
Arthritis research & therapy 2005;7;R1072-81 — 2005 — R1072-81
Diffuse alveolar hemorrhage and pulmonary capillaritis due to propylthiouracil.
Chest 1999 Nov;116;1485-8 — 1999 Nov — 1485-8
Wegener's granulomatosis in a patient receiving propylthiouracil for Graves' disease.
Seminars in arthritis and rheumatism 1998 Oct;28;124-9 — 1998 Oct — 124-9