The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Lee JY, Chung JH, Lee YJ, Park SS, Kim SY, Koo HK, Lee JH, Lee CT, Yoon HI

Propylthiouracil-induced nonspecific interstitial pneumonia.

Chest 2011 Mar;139;687-690 — 2011 Mar — 687-690

Ohwada R, Kato K, Ohmori K, Isozaki O, Hotta M, Ono M, Takano K

A man with interstitial pneumonia due to propylthiouracil.

Internal medicine (Tokyo, Japan) 2003 Oct;42;1026-30 — 2003 Oct — 1026-30

Miyazono K, Okazaki T, Uchida S, Totsuka Y, Matsumoto T, Ogata E, Terakawa K, Kurihara N, Takeda T

Propylthiouracil-induced diffuse interstitial pneumonitis.

Archives of internal medicine 1984 Sep;144;1764-5 — 1984 Sep — 1764-5