The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLII.b

Pneumorenal syndrome (w/wo ANCAs)

Publications

Boattini M, Rodrigues A, Nascimento P, Luz KC, Castelo Branco S, Rodrigues N, Cachado P, Garcia T

Propylthiouracil induced pulmonary-renal syndrome: a case report.

Acta reumatologica portuguesa 2015 Apr-Jun;40;190-2 — 2015 Apr-Jun — 190-2

Fujieda M, Hattori M, Kurayama H, Koitabashi Y,

Clinical features and outcomes in children with antineutrophil cytoplasmic autoantibody-positive glomerulonephritis associated with propylthiouracil treatment.

Journal of the American Society of Nephrology : JASN 2002 Feb;13;437-45 — 2002 Feb — 437-45