The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

III.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Kang DH, Song MK, Ju SH, Lee SI, Kang YE

Propylthiouracil-Induced Antineutrophil Cytoplasmic Antibody-Positive Vasculitis and Agranulocytosis: A Rare Case with Life-Threatening Multiple Systemic Manifestations.

Endocrinology and metabolism (Seoul, Korea). 2023;38(2):282-284

Alidoost M, Cheng J, Alpert DR

Propylthiouracil-Induced Anti-Neutrophil Cytoplasmic Antibody Vasculitis Presenting with Red Eye Followed by Pulmonary Hemorrhage: Diagnostic and Management Considerations.

The American journal of case reports. 2020;21:e925200

Aydın B, Aksu O, Kacemer H, Demirkan H, Altuntaş A, Dirican N, Köroğlu BK, Şahin M

Propylthiouracil-induced alveolar hemorrhage.

European journal of rheumatology. 2015;2(3):114-116

Chen B, Yang X, Sun S, Guo W, Li X, Zhang L, Guo Z, Han J, Li N

Propylthiouracil-Induced Vasculitis With Alveolar Hemorrhage Confirmed by Clinical, Laboratory, Computed Tomography, and Bronchoscopy Findings: A Case Report and Literature Review.

Iranian Red Crescent medical journal. 2016;18(4):e23320

Paiaulla S, Venkategowda PM, Rao SM, Balaraju B

Propylthiouracil-induced autoimmune disease.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine. 2015;19(8):484-6

Boattini M, Rodrigues A, Nascimento P, Luz KC, Castelo Branco S, Rodrigues N, Cachado P, Garcia T

Propylthiouracil induced pulmonary-renal syndrome: a case report.

Acta reumatologica portuguesa. 2015;40(2):190-2

Ortiz-Diaz EO

A 27-year-old woman presenting with refractory hypoxaemic respiratory failure, haemoptysis and thyrotoxicosis: a rare manifestation of propylthiouracil therapy.

BMJ case reports. 2014;2014

Nakazawa D, Tomaru U, Suzuki A, Masuda S, Hasegawa R, Kobayashi T, Nishio S, Kasahara M, Ishizu A

Abnormal conformation and impaired degradation of propylthiouracil-induced neutrophil extracellular traps: implications of disordered neutrophil extracellular traps in a rat model of myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculiti

Arthritis and rheumatism. 2012;64(11):3779-87

Buendía-Roldán I, Navarro C, Rojas-Serrano J

[Diffuse alveolar hemorrhage: Causes and outcomes in a referral center].

Reumatologia clinica. 2010;6(4):196-8

Tu YL, Tsai YC, Huang JL, Yao TC

Occult pulmonary hemorrhage as a rare presentation of propylthiouracil-induced vasculitis.

Pediatrics. 2011;127(1):e245-9

Irani F, Elkambergy H, Naraharisetty K, Jamal R

Propylthiouracil-induced leucocytoclastic vasculitis with pulmonary hemorrhage treated with plasmapheresis.

The American journal of the medical sciences. 2009;337(6):470-2

El-Fakih R, Chehab BM, Shaver T

Thionamide-induced vasculitis: a case of alveolar haemorrhage secondary to propylthiouracil.

Journal of internal medicine. 2008;264(6):610-2

Batchelor N, Holley A

A fatal case of propylthiouracil-induced ANCA-positive vasculitis.

MedGenMed : Medscape general medicine. 2006;8(4):10

Hadjiangelis NP, Harkin TJ

Propylthiouracil-related diffuse alveolar hemorrhage with negative serologies and without capillaritis.

Respiratory medicine. 2007;101(4):865-7

Nakamori Y, Tominaga T, Inoue Y, Shinohara K

Propylthiouracil (PTU)-induced vasculitis associated with antineutrophil antibody against myeloperoxidase (MPO-ANCA).

Internal medicine (Tokyo, Japan). 2003;42(6):529-33

Fujieda M, Hattori M, Kurayama H, Koitabashi Y

Clinical features and outcomes in children with antineutrophil cytoplasmic autoantibody-positive glomerulonephritis associated with propylthiouracil treatment.

Journal of the American Society of Nephrology : JASN. 2002;13(2):437-445

Dhillon SS, Singh D, Doe N, Qadri AM, Ricciardi S, Schwarz MI

Diffuse alveolar hemorrhage and pulmonary capillaritis due to propylthiouracil.

Chest. 1999;116(5):1485-8

Pillinger M, Staud R

Wegener's granulomatosis in a patient receiving propylthiouracil for Graves' disease.

Seminars in arthritis and rheumatism. 1998;28(2):124-9

Stankus SJ, Johnson NT

Propylthiouracil-induced hypersensitivity vasculitis presenting as respiratory failure.

Chest. 1992;102(5):1595-6