The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLII.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Kang DH, Song MK, Ju SH, Lee SI, Kang YE

Propylthiouracil-Induced Antineutrophil Cytoplasmic Antibody-Positive Vasculitis and Agranulocytosis: A Rare Case with Life-Threatening Multiple Systemic Manifestations.

Endocrinology and metabolism (Seoul, Korea) 2023 Mar 13;; — 2023 Mar 13

Alidoost M, Cheng J, Alpert DR

Propylthiouracil-Induced Anti-Neutrophil Cytoplasmic Antibody Vasculitis Presenting with Red Eye Followed by Pulmonary Hemorrhage: Diagnostic and Management Considerations.

The American journal of case reports 2020 Dec 09;21;e925200 — 2020 Dec 09 — e925200

Ayd?n B, Aksu O, Kacemer H, Demirkan H, Altunta? A, Dirican N, Köro?lu BK, ?ahin M

Propylthiouracil-induced alveolar hemorrhage.

European journal of rheumatology 2015 Sep;2;114-116 — 2015 Sep — 114-116

Chen B, Yang X, Sun S, Guo W, Li X, Zhang L, Guo Z, Han J, Li N

Propylthiouracil-Induced Vasculitis With Alveolar Hemorrhage Confirmed by Clinical, Laboratory, Computed Tomography, and Bronchoscopy Findings: A Case Report and Literature Review.

Iranian Red Crescent medical journal 2016 Apr;18;e23320 — 2016 Apr — e23320

Paiaulla S, Venkategowda PM, Rao SM, Balaraju B

Propylthiouracil-induced autoimmune disease.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 2015 Aug;19;484-6 — 2015 Aug — 484-6

Boattini M, Rodrigues A, Nascimento P, Luz KC, Castelo Branco S, Rodrigues N, Cachado P, Garcia T

Propylthiouracil induced pulmonary-renal syndrome: a case report.

Acta reumatologica portuguesa 2015 Apr-Jun;40;190-2 — 2015 Apr-Jun — 190-2

Ortiz-Diaz EO

A 27-year-old woman presenting with refractory hypoxaemic respiratory failure, haemoptysis and thyrotoxicosis: a rare manifestation of propylthiouracil therapy.

BMJ case reports 2014 Aug 22;2014; — 2014 Aug 22

Nakazawa D, Tomaru U, Suzuki A, Masuda S, Hasegawa R, Kobayashi T, Nishio S, Kasahara M, Ishizu A

Abnormal conformation and impaired degradation of propylthiouracil-induced neutrophil extracellular traps: implications of disordered neutrophil extracellular traps in a rat model of myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculiti

Arthritis and rheumatism 2012 Nov;64;3779-87 — 2012 Nov — 3779-87

Buendía-Roldán I, Navarro C, Rojas-Serrano J

[Diffuse alveolar hemorrhage: Causes and outcomes in a referral center].

Reumatologia clinica 2010 Jul-Aug;6;196-8 — 2010 Jul-Aug — 196-8

Tu YL, Tsai YC, Huang JL, Yao TC

Occult pulmonary hemorrhage as a rare presentation of propylthiouracil-induced vasculitis.

Pediatrics 2011 Jan;127;e245-9 — 2011 Jan — e245-9

Irani F, Elkambergy H, Naraharisetty K, Jamal R

Propylthiouracil-induced leucocytoclastic vasculitis with pulmonary hemorrhage treated with plasmapheresis.

The American journal of the medical sciences 2009 Jun;337;470-2 — 2009 Jun — 470-2

El-Fakih R, Chehab BM, Shaver T

Thionamide-induced vasculitis: a case of alveolar haemorrhage secondary to propylthiouracil.

Journal of internal medicine 2008 Dec;264;610-2 — 2008 Dec — 610-2

Batchelor N, Holley A

A fatal case of propylthiouracil-induced ANCA-positive vasculitis.

MedGenMed : Medscape general medicine 2006 Oct 12;8;10 — 2006 Oct 12 — 10

Hadjiangelis NP, Harkin TJ

Propylthiouracil-related diffuse alveolar hemorrhage with negative serologies and without capillaritis.

Respiratory medicine 2007 Apr;101;865-7 — 2007 Apr — 865-7

Nakamori Y, Tominaga T, Inoue Y, Shinohara K

Propylthiouracil (PTU)-induced vasculitis associated with antineutrophil antibody against myeloperoxidase (MPO-ANCA).

Internal medicine (Tokyo, Japan) 2003 Jun;42;529-33 — 2003 Jun — 529-33

Fujieda M, Hattori M, Kurayama H, Koitabashi Y,

Clinical features and outcomes in children with antineutrophil cytoplasmic autoantibody-positive glomerulonephritis associated with propylthiouracil treatment.

Journal of the American Society of Nephrology : JASN 2002 Feb;13;437-45 — 2002 Feb — 437-45

Dhillon SS, Singh D, Doe N, Qadri AM, Ricciardi S, Schwarz MI

Diffuse alveolar hemorrhage and pulmonary capillaritis due to propylthiouracil.

Chest 1999 Nov;116;1485-8 — 1999 Nov — 1485-8

Pillinger M, Staud R

Wegener's granulomatosis in a patient receiving propylthiouracil for Graves' disease.

Seminars in arthritis and rheumatism 1998 Oct;28;124-9 — 1998 Oct — 124-9

Stankus SJ, Johnson NT

Propylthiouracil-induced hypersensitivity vasculitis presenting as respiratory failure.

Chest 1992 Nov;102;1595-6 — 1992 Nov — 1595-6