The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLII.d

Alveolar hemorrhage, diffuse (ANCA-positive/-related)

Publications

Chen B, Yang X, Sun S, Guo W, Li X, Zhang L, Guo Z, Han J, Li N

Propylthiouracil-Induced Vasculitis With Alveolar Hemorrhage Confirmed by Clinical, Laboratory, Computed Tomography, and Bronchoscopy Findings: A Case Report and Literature Review.

Iranian Red Crescent medical journal 2016 Apr;18;e23320 — 2016 Apr — e23320

Paiaulla S, Venkategowda PM, Rao SM, Balaraju B

Propylthiouracil-induced autoimmune disease.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 2015 Aug;19;484-6 — 2015 Aug — 484-6

Kimura M, Seki T, Ozawa H, Ishihara T, Komatsu M, Tajiri S, Yanagi H, Nishina M, Noh JY, Fukagawa M, Takagi A

The onset of antineutrophil cytoplasmic antibody-associated vasculitis immediately after methimazole was switched to propylthiouracil in a woman with Graves' disease who wished to become pregnant.

Endocrine journal 2013;60;383-8 — 2013 — 383-8

Tetikkurt C, Yuruyen M, Tetikkurt S, Bayar N, Ozdemir I

Propylthiouracil-induced lupus-like or vasculitis syndrome.

Multidisciplinary respiratory medicine 2012 Jul 17;7;14 — 2012 Jul 17 — 14

Cordier JF, Cottin V

Alveolar hemorrhage in vasculitis: primary and secondary.

Seminars in respiratory and critical care medicine 2011 Jun;32;310-21 — 2011 Jun — 310-21

Irani F, Elkambergy H, Naraharisetty K, Jamal R

Propylthiouracil-induced leucocytoclastic vasculitis with pulmonary hemorrhage treated with plasmapheresis.

The American journal of the medical sciences 2009 Jun;337;470-2 — 2009 Jun — 470-2

El-Fakih R, Chehab BM, Shaver T

Thionamide-induced vasculitis: a case of alveolar haemorrhage secondary to propylthiouracil.

Journal of internal medicine 2008 Dec;264;610-2 — 2008 Dec — 610-2

Batchelor N, Holley A

A fatal case of propylthiouracil-induced ANCA-positive vasculitis.

MedGenMed : Medscape general medicine 2006 Oct 12;8;10 — 2006 Oct 12 — 10

Kang AY, Baek YH, Sohn YJ, Lee SK, Son CH, Kim K, Yang DK

Diffuse alveolar hemorrhage associated with antineutrophil cytoplasmic antibody levels in a pregnant woman taking propylthiouracil.

The Korean journal of internal medicine 2006 Dec;21;240-3 — 2006 Dec — 240-3

Zhao MH, Chen M, Gao Y, Wang HY

Propylthiouracil-induced anti-neutrophil cytoplasmic antibody-associated vasculitis.

Kidney international 2006 Apr;69;1477-81 — 2006 Apr — 1477-81

Pirot AL, Goldsmith D, Pascasio J, Beck SE

Pulmonary capillaritis with hemorrhage due to propylthiouracil therapy in a child.

Pediatric pulmonology 2005 Jan;39;88-92 — 2005 Jan — 88-92

Yamauchi K, Sata M, Machiya J, Osaka D, Wada T, Abe S, Otake K, Kubota I

Antineutrophil cytoplasmic antibody positive alveolar haemorrhage during propylthiouracil therapy for hyperthyroidism.

Respirology (Carlton, Vic.) 2003 Dec;8;532-5 — 2003 Dec — 532-5

Katayama K, Hata C, Kagawa K, Noda M, Nakamura K, Shimizu H, Fujimoto M

Diffuse alveolar hemorrhage associated with myeloperoxidase-antineutrophil cytoplasmic antibody induced by propylthiouracil therapy.

Respiration; international review of thoracic diseases 2002;69;473 — 2002 — 473

Dhillon SS, Singh D, Doe N, Qadri AM, Ricciardi S, Schwarz MI

Diffuse alveolar hemorrhage and pulmonary capillaritis due to propylthiouracil.

Chest 1999 Nov;116;1485-8 — 1999 Nov — 1485-8

Stankus SJ, Johnson NT

Propylthiouracil-induced hypersensitivity vasculitis presenting as respiratory failure.

Chest 1992 Nov;102;1595-6 — 1992 Nov — 1595-6