The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

III.d

Alveolar hemorrhage, diffuse (ANCA-positive/-related)

Publications

Chen B, Yang X, Sun S, Guo W, Li X, Zhang L, Guo Z, Han J, Li N

Propylthiouracil-Induced Vasculitis With Alveolar Hemorrhage Confirmed by Clinical, Laboratory, Computed Tomography, and Bronchoscopy Findings: A Case Report and Literature Review.

Iranian Red Crescent medical journal. 2016;18(4):e23320

Paiaulla S, Venkategowda PM, Rao SM, Balaraju B

Propylthiouracil-induced autoimmune disease.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine. 2015;19(8):484-6

Kimura M, Seki T, Ozawa H, Ishihara T, Komatsu M, Tajiri S, Yanagi H, Nishina M, Noh JY, Fukagawa M, Takagi A

The onset of antineutrophil cytoplasmic antibody-associated vasculitis immediately after methimazole was switched to propylthiouracil in a woman with Graves' disease who wished to become pregnant.

Endocrine journal. 2013;60(3):383-8

Tetikkurt C, Yuruyen M, Tetikkurt S, Bayar N, Ozdemir I

Propylthiouracil-induced lupus-like or vasculitis syndrome.

Multidisciplinary respiratory medicine. 2012;7(1):14

Cordier JF, Cottin V

Alveolar hemorrhage in vasculitis: primary and secondary.

Seminars in respiratory and critical care medicine. 2011;32(3):310-21

Irani F, Elkambergy H, Naraharisetty K, Jamal R

Propylthiouracil-induced leucocytoclastic vasculitis with pulmonary hemorrhage treated with plasmapheresis.

The American journal of the medical sciences. 2009;337(6):470-2

El-Fakih R, Chehab BM, Shaver T

Thionamide-induced vasculitis: a case of alveolar haemorrhage secondary to propylthiouracil.

Journal of internal medicine. 2008;264(6):610-2

Batchelor N, Holley A

A fatal case of propylthiouracil-induced ANCA-positive vasculitis.

MedGenMed : Medscape general medicine. 2006;8(4):10

Kang AY, Baek YH, Sohn YJ, Lee SK, Son CH, Kim K, Yang DK

Diffuse alveolar hemorrhage associated with antineutrophil cytoplasmic antibody levels in a pregnant woman taking propylthiouracil.

The Korean journal of internal medicine. 2006;21(4):240-3

Zhao MH, Chen M, Gao Y, Wang HY

Propylthiouracil-induced anti-neutrophil cytoplasmic antibody-associated vasculitis.

Kidney international. 2006;69(8):1477-81

Pirot AL, Goldsmith D, Pascasio J, Beck SE

Pulmonary capillaritis with hemorrhage due to propylthiouracil therapy in a child.

Pediatric pulmonology. 2005;39(1):88-92

Yamauchi K, Sata M, Machiya J, Osaka D, Wada T, Abe S, Otake K, Kubota I

Antineutrophil cytoplasmic antibody positive alveolar haemorrhage during propylthiouracil therapy for hyperthyroidism.

Respirology (Carlton, Vic.). 2003;8(4):532-5

Katayama K, Hata C, Kagawa K, Noda M, Nakamura K, Shimizu H, Fujimoto M

Diffuse alveolar hemorrhage associated with myeloperoxidase-antineutrophil cytoplasmic antibody induced by propylthiouracil therapy.

Respiration; international review of thoracic diseases. 2002;69(5):473

Dhillon SS, Singh D, Doe N, Qadri AM, Ricciardi S, Schwarz MI

Diffuse alveolar hemorrhage and pulmonary capillaritis due to propylthiouracil.

Chest. 1999;116(5):1485-8

Stankus SJ, Johnson NT

Propylthiouracil-induced hypersensitivity vasculitis presenting as respiratory failure.

Chest. 1992;102(5):1595-6