The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.ak

Dual MPO-/PR3-ANCA systemic disease/vasculitis/pseudovasculitis

Publications

Kang DH, Song MK, Ju SH, Lee SI, Kang YE

Propylthiouracil-Induced Antineutrophil Cytoplasmic Antibody-Positive Vasculitis and Agranulocytosis: A Rare Case with Life-Threatening Multiple Systemic Manifestations.

Endocrinology and metabolism (Seoul, Korea). 2023;38(2):282-284

Hasegawa A, Fujimoto A, Yuki D, Hayashi R, Aizawa A, Ito T, Abe R

PR3-ANCA: a potential biomarker of disease activity for propylthiouracil-induced ANCA-associated vasculitis.

European journal of dermatology : EJD. 2018;28(4):530-531

Schamp V, Verfaillie C, Bonroy C, Vande Walle J, Raes A, Dehoorne J

Propylthiouracil induced ANCA-associated vasculitis in a 14-year-old girl.

Acta clinica Belgica. 2015;70(2):127-9