The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLI.e

ARDS - Acute lung injury

Publications

Kang DH, Song MK, Ju SH, Lee SI, Kang YE

Propylthiouracil-Induced Antineutrophil Cytoplasmic Antibody-Positive Vasculitis and Agranulocytosis: A Rare Case with Life-Threatening Multiple Systemic Manifestations.

Endocrinology and metabolism (Seoul, Korea) 2023 Mar 13;; — 2023 Mar 13

Chevrolet JC, Guelpa G, Schifferli JA

Recurrent adult respiratory distress-like syndrome associated with propylthiouracil therapy.

The European respiratory journal 1991 Jul;4;899-901 — 1991 Jul — 899-901

Stankus SJ, Johnson NT

Propylthiouracil-induced hypersensitivity vasculitis presenting as respiratory failure.

Chest 1992 Nov;102;1595-6 — 1992 Nov — 1595-6