Philippe Camus, M.D.

Dijon, France

Both apps are now back!

Back

The Drug-Induced Respiratory Disease Website and App

Trimethoprim sulfamethoxazole (TMP-SMX)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I - Interstitial/parenchymal lung disease

I.a

Pneumonitis (interstitial lung disease/ILD)
I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)
I.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
I.d

Acute eosinophilic pneumonia (AEP)
I.f

Acute fibrinous organizing pneumonia (AFOP)
I.bb

Irreversible respiratory damage requiring lung Tx

XLI - Pulmonary edema - Acute lung injury - ARDS

XLI.a

Pulmonary edema, noncardiogenic (NCPE)
XLI.e

ARDS - Acute lung injury
XLI.u

Acute respiratory failure (e.g. from ARDS, ILD, PIE, OP, pulmonary edema or bronchospasm) requiring ECMO

XLV - Pleural and/or pericardial involvement

XLV.f

Pneumothorax

XLVII - Mediastinal involvement

XLVII.h

Pneumomediastinum

XLIX - Systemic/Distant conditions, syndromes and reactions

XLIX.a

DRES syndrome - DRESS-like reaction
XLIX.e

Autoimmunity-Autoimmune conditions (+ANA, +anti-ds-DNA, +ANCAs, other auto-Abs)
XLIX.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)
XLIX.i

Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)
XLIX.z

ANCA positivity. Subclinical or with clinical manifestations

LIII - Hemoglobinopathies - Abnormal hemoglobin states (acquired)

LIII.a

Methemoglobinemia

LV - Imaging

LV.f

Imaging: Bibasilar opacities/shadowing
LV.bd

Imaging: Pneumomediastinum

LVII - Cytological, biochemical features of/in BAL, pleural fluid or FNA

LVII.a

BAL: An excess proportion of lymphocytes
LVII.c

BAL: An excess proportion of eosinophils

LVIII - Pathology

LVIII.a

Path: NSIP-cellular pattern (see also Ia, Ib)
LVIII.b

Path: Eosinophilic pneumonia (subacute or acute) (see also Ic)
LVIII.o

Path: Diffuse alveolar damage (DAD-pattern) (see also IL)
LVIII.p

Path: Resolving alveolar damage
LVIII.v

Path: NSIP-fibrotic pattern
LVIII.cw

Path: Delayed Alveolar Injury with Delayed Epithelialization (DAIDE)