The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Afflu DK, Cody BA, Lendermon E, Sanchez PG

The use of bilateral orthotopic lung transplantation in the management of acute severe drug-induced interstitial lung disease: A case report.

JHLT open 2024 Aug;5;100108 — 2024 Aug — 100108

Givry F, Lebargy F, Lebrun D, Bonnet M, Ruellan AL, Hentzien M, Azzouz B, Bani-Sadr F

Lung toxicity related to trimethoprim/sulfamethoxazole: pharmacovigilance data review.

The Journal of antimicrobial chemotherapy 2025 Apr 02;80 — 2025 Apr 02 — 1148-1152

Rubin J, Chiu ML, Mino-Kenudson M, Sharma A, Witkin AS, Moschovis PP, Vogel Y, Shelton K, Crowley J, Raz Y

ARDS With Pneumothorax in a Young Adult.

Chest 2022 Feb;161;e111-e116 — 2022 Feb — e111-e116

Miller JO, Shih AR, Mino-Kenudson M, Taylor MS, Goldman JL

Trimethoprim-Sulfamethoxazole Associated Fulminant Respiratory Failure in Children and Young Adults.

American journal of respiratory and critical care medicine 2021 Jan 29;; — 2021 Jan 29

Yuzurio S, Horita N, Shiota Y, Kanehiro A, Tanimoto M

Interstitial lung disease during trimethoprim/sulfamethoxazole administration.

Acta medica Okayama 2010 Jun;64;181-7 — 2010 Jun — 181-7

Oshitani N, Matsumoto T, Moriyama Y, Kudoh S, Hirata K, Kuroki T

Drug-induced pneumonitis caused by sulfamethoxazole, trimethoprim during treatment of Pneumocystis carinii pneumonia in a patient with refractory ulcerative colitis.

Journal of gastroenterology 1998 Aug;33;578-81 — 1998 Aug — 578-81

Cass RM

Adult respiratory distress syndrome and trimethoprim-sulfamethoxazole.

Annals of internal medicine 1987 Feb;106;331 — 1987 Feb — 331