The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (interstitial lung disease/ILD)

Publications

Afflu DK, Cody BA, Lendermon E, Sanchez PG

The use of bilateral orthotopic lung transplantation in the management of acute severe drug-induced interstitial lung disease: A case report.

JHLT open. 2024;5:100108

Givry F, Lebargy F, Lebrun D, Bonnet M, Ruellan AL, Hentzien M, Azzouz B, Bani-Sadr F

Lung toxicity related to trimethoprim/sulfamethoxazole: pharmacovigilance data review.

The Journal of antimicrobial chemotherapy. 2025;80(4):1148-1152

Rubin J, Chiu ML, Mino-Kenudson M, Sharma A, Witkin AS, Moschovis PP, Vogel Y, Shelton K, Crowley J, Raz Y

ARDS With Pneumothorax in a Young Adult.

Chest. 2022;161(2):e111-e116

Miller JO, Shih AR, Mino-Kenudson M, Taylor MS, Goldman JL

Trimethoprim-Sulfamethoxazole-associated Fulminant Respiratory Failure in Children and Young Adults.

American journal of respiratory and critical care medicine. 2021;203(7):918-921

Yuzurio S, Horita N, Shiota Y, Kanehiro A, Tanimoto M

Interstitial lung disease during trimethoprim/sulfamethoxazole administration.

Acta medica Okayama. 2010;64(3):181-7

Oshitani N, Matsumoto T, Moriyama Y, Kudoh S, Hirata K, Kuroki T

Drug-induced pneumonitis caused by sulfamethoxazole, trimethoprim during treatment of Pneumocystis carinii pneumonia in a patient with refractory ulcerative colitis.

Journal of gastroenterology. 1998;33(4):578-81

Cass RM

Adult respiratory distress syndrome and trimethoprim-sulfamethoxazole.

Annals of internal medicine. 1987;106(2):331