The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
Publications
The use of bilateral orthotopic lung transplantation in the management of acute severe drug-induced interstitial lung disease: A case report.
JHLT open 2024 Aug;5;100108 — 2024 Aug — 100108
Lung toxicity related to trimethoprim/sulfamethoxazole: pharmacovigilance data review.
The Journal of antimicrobial chemotherapy 2025 Apr 02;80 — 2025 Apr 02 — 1148-1152
Mochizuka Y, Fujisawa T, Inoue Y, Hozumi H, Suzuki Y, Karayama M, Furuhashi K, Enomoto N, Nakamura Y, Inui N, Suda T
Trimethoprim-sulfamethoxazole induced eosinophilic pneumonia: A case report.
Respiratory medicine case reports 2022;37;101632 — 2022 — 101632
Sulfa-induced acute eosinophilic pneumonia.
Respiratory medicine case reports 2021;34;101496 — 2021 — 101496
[Drug induced interstitial lung diseases after treatment with cotrimoxazole. 2 cases].
La Nouvelle presse medicale 1980 Sep 20;9;2347 — 1980 Sep 20 — 2347
Hypersensitivity pneumonitis induced by trimethoprim.
BMJ (Clinical research ed.) 1990 May 19;300;1344 — 1990 May 19 — 1344