The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLI.e

ARDS - Acute lung injury

Publications

Afflu DK, Cody BA, Lendermon E, Sanchez PG

The use of bilateral orthotopic lung transplantation in the management of acute severe drug-induced interstitial lung disease: A case report.

JHLT open 2024 Aug;5;100108 — 2024 Aug — 100108

Givry F, Lebargy F, Lebrun D, Bonnet M, Ruellan AL, Hentzien M, Azzouz B, Bani-Sadr F

Lung toxicity related to trimethoprim/sulfamethoxazole: pharmacovigilance data review.

The Journal of antimicrobial chemotherapy 2025 Apr 02;80 — 2025 Apr 02 — 1148-1152

Huang P, Kam KQ, Tan YH, Lee MP, Chan SB, Lee JH

Trimethoprim-sulfamethoxazole-induced lung injury: a case report.

Translational pediatrics 2023 Nov 28;12;2062-2073 — 2023 Nov 28 — 2062-2073

Natterer J, Rizzati F, Perez MH, Longchamp D, Amiet V, DeHalleux Q, Dao K, Ferry T

Suspected Case of Drug-Induced Acute Respiratory Distress Syndrome following Trimethoprim-Sulfamethoxazole Treatment.

Journal of pediatric intensive care 2022 Mar;11;67-71 — 2022 Mar — 67-71

Rubin J, Chiu ML, Mino-Kenudson M, Sharma A, Witkin AS, Moschovis PP, Vogel Y, Shelton K, Crowley J, Raz Y

ARDS With Pneumothorax in a Young Adult.

Chest 2022 Feb;161;e111-e116 — 2022 Feb — e111-e116

Miller JO, Shih AR, Mino-Kenudson M, Taylor MS, Goldman JL

Trimethoprim-Sulfamethoxazole Associated Fulminant Respiratory Failure in Children and Young Adults.

American journal of respiratory and critical care medicine 2021 Jan 29;; — 2021 Jan 29

Miller JO, Taylor J, Goldman JL

Severe Acute Respiratory Failure in Healthy Adolescents Exposed to Trimethoprim-Sulfamethoxazole.

Pediatrics 2019 Jun;143; — 2019 Jun

Silvestri RC, Jensen WA, Zibrak JD, Alexander RC, Rose RM

Pulmonary infiltrates and hypoxemia in patients with the acquired immunodeficiency syndrome re-exposed to trimethoprim-sulfamethoxazole.

The American review of respiratory disease 1987 Oct;136;1003-4 — 1987 Oct — 1003-4

Cass RM

Adult respiratory distress syndrome and trimethoprim-sulfamethoxazole.

Annals of internal medicine 1987 Feb;106;331 — 1987 Feb — 331

Arnold PA, Guglielmo BJ, Hollander H

Severe hypersensitivity reaction upon rechallenge with trimethoprim-sulfamethoxazole in a patient with AIDS.

Drug intelligence & clinical pharmacy 1988 Jan;22;43-5 — 1988 Jan — 43-5