The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

Publications

Afflu DK, Cody BA, Lendermon E, Sanchez PG

The use of bilateral orthotopic lung transplantation in the management of acute severe drug-induced interstitial lung disease: A case report.

JHLT open 2024 Aug;5;100108 — 2024 Aug — 100108

Huang P, Kam KQ, Tan YH, Lee MP, Chan SB, Lee JH

Trimethoprim-sulfamethoxazole-induced lung injury: a case report.

Translational pediatrics 2023 Nov 28;12;2062-2073 — 2023 Nov 28 — 2062-2073

Rubin J, Chiu ML, Mino-Kenudson M, Sharma A, Witkin AS, Moschovis PP, Vogel Y, Shelton K, Crowley J, Raz Y

ARDS With Pneumothorax in a Young Adult.

Chest 2022 Feb;161;e111-e116 — 2022 Feb — e111-e116