The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.a

DRES syndrome - DRESS-like reaction

Publications

Derungs A, Rätz Bravo AE, Kummer O

[Rash, fever, eosinophilia and elevated liver enzymes. DRESS syndrome (drug reaction or rash with eosinophilia and systemic symptoms)].

Praxis. 2010;99(13):767-77; quiz 776

Payne FE Jr, Giesecke TF

Multiple system reaction to trimethoprim-sulfamethoxazole.

Southern medical journal. 1987;80(2):275-6

Brøckner J, Bøisen E

Fatal multisystem toxicity after co-trimoxazole.

Lancet (London, England). 1978;1(8068):831

Finlayson WB, Johnson G

Multisystem toxicity after co-trimoxazole.

Lancet (London, England). 1978;2(8091):682-3