The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.a

Pulmonary edema, noncardiogenic (NCPE)

Publications

Silvestri RC, Jensen WA, Zibrak JD, Alexander RC, Rose RM

Pulmonary infiltrates and hypoxemia in patients with the acquired immunodeficiency syndrome re-exposed to trimethoprim-sulfamethoxazole.

The American review of respiratory disease 1987 Oct;136;1003-4 — 1987 Oct — 1003-4

Ulstad DR, Ampel NM, Shon BY, Galgiani JN, Cutcher AB

Reaction after re-exposure to trimethoprim-sulfamethoxazole.

Chest 1989 Apr;95;937-8 — 1989 Apr — 937-8

Holdcroft CJ, Ellison RT

Trimethoprim-sulfamethoxazole reaction simulating Pneumocystis carinii pneumonia.

AIDS (London, England) 1991 Aug;5;1029 — 1991 Aug — 1029