The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
BAL: An excess proportion of eosinophils
Publications
Delayed-onset pulmonary toxicity by trimethoprim-sulfamethoxazole.
Enfermedades infecciosas y microbiologia clinica (English ed.) 2026 May;44 — 2026 May — 503147
Mochizuka Y, Fujisawa T, Inoue Y, Hozumi H, Suzuki Y, Karayama M, Furuhashi K, Enomoto N, Nakamura Y, Inui N, Suda T
Trimethoprim-sulfamethoxazole induced eosinophilic pneumonia: A case report.
Respiratory medicine case reports 2022;37;101632 — 2022 — 101632