The Drug-Induced Respiratory Disease Website and App

I. Interstitial/parenchymal lung disease

I.a Pneumonitis (interstitial lung disease/ILD)

I. Interstitial/parenchymal lung disease

I.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

I. Interstitial/parenchymal lung disease

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

I. Interstitial/parenchymal lung disease

I.d Acute eosinophilic pneumonia (AEP)

I. Interstitial/parenchymal lung disease

I.e Organizing pneumonia pattern (an area or areas of consolidation on imaging)

I. Interstitial/parenchymal lung disease

I.f Acute fibrinous organizing pneumonia (AFOP)

I. Interstitial/parenchymal lung disease

I.g Pulmonary fibrosis

I. Interstitial/parenchymal lung disease

I.v Relapsing or migrating pneumonitis/pneumonia (see also Id)

I. Interstitial/parenchymal lung disease

I.w Abnormal lung function/pulmonary physiology (PFTs) without necessarily imaging or clinical evidence

I. Interstitial/parenchymal lung disease

I.x Rapidly progressive ILD/pulmonary fibrosis (Hamman-Rich syndrome)

I. Interstitial/parenchymal lung disease

I.z Progression, acceleration or exacerbation of preexisting ILD/fibrosis

I. Interstitial/parenchymal lung disease

I.ab Delayed ILD, -pneumonitis, -fibrosis

I. Interstitial/parenchymal lung disease

I.ae Radiation recall pneumonitis

I. Interstitial/parenchymal lung disease

I.ak Shrinking lung syndrome

I. Interstitial/parenchymal lung disease

I.ay Chronic pneumonitis

XLI. Pulmonary edema - Acute lung injury - ARDS

XLI.b Pulmonary edema, cardiogenic

XLI. Pulmonary edema - Acute lung injury - ARDS

XLI.e ARDS - Acute lung injury

XLII. Pulmonary/alveolar./airway hemorrhage/bleeding

XLII.m Coagulopathy

XLIII. Airway involvement

XLIII.a Bronchospasm - Wheezing - Asthma

XLIII. Airway involvement

XLIII.d Exacerbation or deterioration of preexisting COPD

XLIII. Airway involvement

XLIII.t Eosinophilic airway disease (asthma, bronchitis, bronchiolitis)

XLIII. Airway involvement

XLIII.x Obliterative bronchiolitis (a pattern consistent with) (see also IVn, XVx)

XLIII. Airway involvement

XLIII.af Sputum production - Bonchorrhea - ‘Bronchitis’

XLIII. Airway involvement

XLIII.ag Obstructive airway dysfunction (see also IVc, XVx)

XLIV. Central-large-upper airway (incl. pharyngeal-nasal) involvement

XLIV.g Vocal cord paresis/paralysis

XLV. Pleural and/or pericardial involvement

XLV.a Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

XLV. Pleural and/or pericardial involvement

XLV.i Pleuritis (can cause chest pain)

XLV. Pleural and/or pericardial involvement

XLV.t Serositis - Polyserositis

XLVI. Pulmonary vasculopathy

XLVI.a Pulmonary embolism - Venous thrombosis/thromboembolism

XLVI. Pulmonary vasculopathy

XLVI.b Pulmonary arterial hypertension

XLVII. Mediastinal involvement

XLVII.a Lymphadenopathy (intrathoracic)

XLVIII. Neuromuscular / CNS involvement - Disordered breathing (during sleep)

XLVIII.a Diaphragm/inspiratory muscle weakness/paralysis (w/wo ARF)

XLVIII. Neuromuscular / CNS involvement - Disordered breathing (during sleep)

XLVIII.d Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

XLVIII. Neuromuscular / CNS involvement - Disordered breathing (during sleep)

XLVIII.r Myasthenia gravis - Myasthenic-like syndrome

XLVIII. Neuromuscular / CNS involvement - Disordered breathing (during sleep)

XLVIII.ab Guillain-Barré (or GB-like) syndrome (w/wo ARF)

XLVIII. Neuromuscular / CNS involvement - Disordered breathing (during sleep)

XLVIII.ac Myositis of the respiratory muscles (May lead to respiratory muscle paralysis)

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.a DRES syndrome - DRESS-like reaction

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.c Capillary leak syndrome (CLS)

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.d Lupus - Lupus syndrome (see also Vd)

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.e Autoimmunity-Autoimmune conditions (+ANA, +anti-ds-DNA, +ANCAs, other auto-Abs)

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.i Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.j Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.l Myopathy-Myositis-Polymyositis (see also under Xba)

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.m Sarcoid-like granulomatosis (endo-/extrathoracic)

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.o Vascultis (pulmonary, extrathoracic or systemic)-ANCA status unknown or negative)

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.p Tumor lysis syndrome (TLS)

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.u Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.w Multiple organ dysfunction/failure (MODS/MOF)

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.ao Immune-related adverse effect/toxicity

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.ap Cytokine release syndrome - Cytokine storm

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.ax Connective tissue disease

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.az Polymyalgia rheumatica

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.bj Temporal arteritis (Horton’s)

L. Miscellaneous

L.l Neutropenia, agranulocytosis (w/wo infection/sepsis)

L. Miscellaneous

L.v Adrenal suppression

L. Miscellaneous

L.ad Vertebral compression fracture

L. Miscellaneous

L.ar Graft vs. host disease in transplant recipients

L. Miscellaneous

L.as Deterioration of graft function in SOT recipients

L. Miscellaneous

L.av Nonrespiratory AE of interest

LI. Cardiovascular involvement / toxicity

LI.a Left or biventricular dysfunction/failure

LI. Cardiovascular involvement / toxicity

LI.c Pericardial effusion (w/wo tamponade)

LI. Cardiovascular involvement / toxicity

LI.d Myocarditis (can be fulminant)

LI. Cardiovascular involvement / toxicity

LI.f Takotsubo (stress) cardiomyopathy

LI. Cardiovascular involvement / toxicity

LI.h Coronary artery disease (acute) - Myocardial ischemia/infarction

LI. Cardiovascular involvement / toxicity

LI.n Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

LI. Cardiovascular involvement / toxicity

LI.o Cardiovascular collapse - Cardiogenic shock - Hypotension

LI. Cardiovascular involvement / toxicity

LI.s Heart failure (biventricular, congestive)

LI. Cardiovascular involvement / toxicity

LI.t Heart block (bundle branch- or AV-)

LI. Cardiovascular involvement / toxicity

LI.ak Cardiotoxicity

LI. Cardiovascular involvement / toxicity

LI.az Necrotizing myocarditis (w/o evidence for CAD)

LI. Cardiovascular involvement / toxicity

LI.bd Sudden cardiac death

LV. Imaging

LV.k Imaging: An area or areas of consolidation

LV. Imaging

LV.v Imaging: Centrilobular micronodules (can be diffuse)

LV. Imaging

LV.w Imaging: Lung nodule or nodules

LV. Imaging

LV.bj Imaging: Avid pleural uptake on PET-scan

LV. Imaging

LV.bk Imaging: F18-PET scan positive lympadenopathy

LV. Imaging

LV.bv Imaging: A subsolid lung nodule or nodules

LVII. Cytological, biochemical features of/in BAL, pleural fluid or FNA

LVII.a BAL: An excess proportion of lymphocytes

LVII. Cytological, biochemical features of/in BAL, pleural fluid or FNA

LVII.b BAL: An excess proportion of neutrophils

LVII. Cytological, biochemical features of/in BAL, pleural fluid or FNA

LVII.c BAL: An excess proportion of eosinophils

LVIII. Pathology

LVIII.a Path: NSIP-cellular pattern (see also Ia, Ib)

LVIII. Pathology

LVIII.b Path: Eosinophilic pneumonia (subacute or acute) (see also Ic)

LVIII. Pathology

LVIII.d Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)

LVIII. Pathology

LVIII.e Path: Acute fibrinous organizing pneumonia (AFOP-pattern) (see also If)

LVIII. Pathology

LVIII.f Path: ILD with a granulomatous component (see also Im)

LVIII. Pathology

LVIII.j Path: Micronodular organizing pneumonia/BOOP

LVIII. Pathology

LVIII.o Path: Diffuse alveolar damage (DAD-pattern) (see also IL)

LVIII. Pathology

LVIII.x Path: Pulmonary fibrosis (not otherwise specified or unclassifiable)

LVIII. Pathology

LVIII.ae Path: Foamy inclusions in alveolar macrophages and/or in other lung cells

LVIII. Pathology

LVIII.al Path: Acute/subacute bronchiolitis (see also IVc, IVi)

LVIII. Pathology

LVIII.bx Path: Granulomatous lymphadenopathy

LVIII. Pathology

LVIII.co Path: Myocarditis

LVIII. Pathology

LVIII.cr Path: Myocardial vasculitis

LVIII. Pathology

LVIII.cv Path: Pneumocyte vacuolization

LIX. Infections & related conditions

LIX.b Opportunistic pulmonary/systemic infections

LIX. Infections & related conditions

LIX.c Aspergillosis, pulmonary (invasive, allergic [ABPA], or mycetoma)

LIX. Infections & related conditions

LIX.e Pneumocystis jiroveci pneumonia

LIX. Infections & related conditions

LIX.g Tuberculosis (pulmonary, pulmonary, extrapulmonary or disseminated). Reactivation or de novo

LIX. Infections & related conditions

LIX.q Viral pneumonia

LIX. Infections & related conditions

LIX.r Fungal infection (pulmonary/extrapulmonary)

I. Interstitial/parenchymal lung disease

I.a Pneumonitis (interstitial lung disease/ILD)

I. Interstitial/parenchymal lung disease

I.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

I. Interstitial/parenchymal lung disease

I.e Organizing pneumonia pattern (an area or areas of consolidation on imaging)

I. Interstitial/parenchymal lung disease

I.n ILD with a granulomatous component

I. Interstitial/parenchymal lung disease

I.w Abnormal lung function/pulmonary physiology (PFTs) without necessarily imaging or clinical evidence

XLI. Pulmonary edema - Acute lung injury - ARDS

XLI.e ARDS - Acute lung injury

XLIII. Airway involvement

XLIII.d Exacerbation or deterioration of preexisting COPD

XLV. Pleural and/or pericardial involvement

XLV.a Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

XLV. Pleural and/or pericardial involvement

XLV.m Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)

XLVII. Mediastinal involvement

XLVII.e Granulomatous mediastinal lymphadenopathy

XLVIII. Neuromuscular / CNS involvement - Disordered breathing (during sleep)

XLVIII.j Phrenic nerve injury - Hemi- or bilateral diaphragmatic paralysis

XLVIII. Neuromuscular / CNS involvement - Disordered breathing (during sleep)

XLVIII.r Myasthenia gravis - Myasthenic-like syndrome

XLVIII. Neuromuscular / CNS involvement - Disordered breathing (during sleep)

XLVIII.ab Guillain-Barré (or GB-like) syndrome (w/wo ARF)

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.a DRES syndrome - DRESS-like reaction

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.e Autoimmunity-Autoimmune conditions (+ANA, +anti-ds-DNA, +ANCAs, other auto-Abs)

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.i Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.l Myopathy-Myositis-Polymyositis (see also under Xba)

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.m Sarcoid-like granulomatosis (endo-/extrathoracic)

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.n Systemic granulomatosis other than Xk

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.q Neutrophilic dermatosis (Pyoderma, Sweet syndrome)

XLIX. Systemic/Distant conditions, syndromes and reactions

XLIX.ao Immune-related adverse effect/toxicity

LI. Cardiovascular involvement / toxicity

LI.c Pericardial effusion (w/wo tamponade)

LI. Cardiovascular involvement / toxicity

LI.d Myocarditis (can be fulminant)

LI. Cardiovascular involvement / toxicity

LI.ba Fulminant myocarditis (See also under XIId)

LI. Cardiovascular involvement / toxicity

LI.bc Fulminate myocarditis

LV. Imaging

LV.bk Imaging: F18-PET scan positive lympadenopathy

LVII. Cytological, biochemical features of/in BAL, pleural fluid or FNA

LVII.a BAL: An excess proportion of lymphocytes

LVIII. Pathology

LVIII.d Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)

LVIII. Pathology

LVIII.bv Path: Fibrinous pericarditis

LIX. Infections & related conditions

LIX.b Opportunistic pulmonary/systemic infections

LIX. Infections & related conditions

LIX.c Aspergillosis, pulmonary (invasive, allergic [ABPA], or mycetoma)