The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLVII.e

Granulomatous mediastinal lymphadenopathy

Publications

Toumeh A, Sakhi R, Shah S, Arudra SK, De Las Casas LE, Skeel RT

Ipilimumab-Induced Granulomatous Disease Occurring Simultaneously With Disease Progression in a Patient With Metastatic Melanoma.

American journal of therapeutics 2016 Jul-Aug;23;e1068-71 — 2016 Jul-Aug — e1068-71

Vogel WV, Guislain A, Kvistborg P, Schumacher TN, Haanen JB, Blank CU

Ipilimumab-induced sarcoidosis in a patient with metastatic melanoma undergoing complete remission.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012 Jan 10;30;e7-e10 — 2012 Jan 10 — e7-e10