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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.k

Sarcoid-like granulomatosis (endo-/extrathoracic)

Can closely mimic on imaging progression of underlying malignancy for which the ICI drug was exactly given. Particularly in the setting of lung cancer (PMID 30745234)

Publications

Sagawa T, Sato Y, Nagashima H, Takada K, Takahashi M, Hirakawa M, Hamaguchi K, Tamura F, Fujikawa K, Okamoto K, Kawano Y, Sogabe M, Miyamoto H, Takayama T

Hilar/mediastinal and cutaneous drug-induced sarcoidosis-like reaction associated with immune checkpoint inhibitors in metastatic colorectal cancer: a case report.

Frontiers in immunology. 2023;14:1203621

Vergnon JM, Tissot CL

[Nivolumab and sarcoid reaction in lung cancer treatment].

Revue des maladies respiratoires. 2019;36(2):230-232

Cornejo CM, Haun P, English J 3rd, Rosenbach M

Immune checkpoint inhibitors and the development of granulomatous reactions.

Journal of the American Academy of Dermatology. 2019;81(5):1165-1175

Gkiozos I, Kopitopoulou A, Kalkanis A, Vamvakaris IN, Judson MA, Syrigos KN

Sarcoidosis-Like Reactions Induced by Checkpoint Inhibitors.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2018;13(8):1076-1082

Chopra A, Nautiyal A, Kalkanis A, Judson MA

Drug-Induced Sarcoidosis-Like Reactions.

Chest. 2018;154(3):664-677

Nishino M, Sholl LM, Awad MM, Hatabu H, Armand P, Hodi FS

Sarcoid-Like Granulomatosis of the Lung Related to Immune-Checkpoint Inhibitors: Distinct Clinical and Imaging Features of a Unique Immune-Related Adverse Event.

Cancer immunology research. 2018;6(6):630-635

Yatim N, Mateus C, Charles P

Sarcoidosis post-anti-PD-1 therapy, mimicking relapse of metastatic melanoma in a patient undergoing complete remission.

La Revue de medecine interne. 2018;39(2):130-133

Reddy SB, Possick JD, Kluger HM, Galan A, Han D

Sarcoidosis Following Anti-PD-1 and Anti-CTLA-4 Therapy for Metastatic Melanoma.

Journal of immunotherapy (Hagerstown, Md. : 1997). 2017;40(8):307-311

Bordry N, Costa-Nunes CM, Cagnon L, Gannon PO, Abed-Maillard S, Baumgaertner P, Murray T, Letovanec I, Lazor R, Bouchaab H, Rufer N, Romano E, Michielin O, Speiser DE

Pulmonary sarcoid-like granulomatosis after multiple vaccinations of a long-term surviving patient with metastatic melanoma.

Cancer immunology research. 2014;2(12):1148-53