The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Sarcoid-like granulomatosis (endo-/extrathoracic)
Can closely mimic on imaging progression of underlying malignancy for which the ICI drug was exactly given. Particularly in the setting of lung cancer (PMID 30745234)
Publications
Sagawa T, Sato Y, Nagashima H, Takada K, Takahashi M, Hirakawa M, Hamaguchi K, Tamura F, Fujikawa K, Okamoto K, Kawano Y, Sogabe M, Miyamoto H, Takayama T
Hilar/mediastinal and cutaneous drug-induced sarcoidosis-like reaction associated with immune checkpoint inhibitors in metastatic colorectal cancer: a case report.
Frontiers in immunology 2023;14;1203621 — 2023 — 1203621
[Nivolumab and sarcoid reaction in lung cancer treatment].
Revue des maladies respiratoires 2019 Feb;36;230-232 — 2019 Feb — 230-232
Immune checkpoint inhibitors and the development of granulomatous reactions.
Journal of the American Academy of Dermatology 2018 Aug 06;; — 2018 Aug 06
Sarcoidosis-Like Reactions Induced by Checkpoint Inhibitors.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2018 08;13;1076-1082 — 2018 08 — 1076-1082
Drug-Induced Sarcoidosis-Like Reactions.
Chest 2018 Sep;154;664-677 — 2018 Sep — 664-677
Sarcoid-Like Granulomatosis of the Lung Related to Immune-Checkpoint Inhibitors: Distinct Clinical and Imaging Features of a Unique Immune-Related Adverse Event.
Cancer immunology research 2018 06;6;630-635 — 2018 06 — 630-635
Sarcoidosis post-anti-PD-1 therapy, mimicking relapse of metastatic melanoma in a patient undergoing complete remission.
La Revue de medecine interne 2018 Feb;39;130-133 — 2018 Feb — 130-133
Sarcoidosis Following Anti-PD-1 and Anti-CTLA-4 Therapy for Metastatic Melanoma.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2017 10;40;307-311 — 2017 10 — 307-311
Bordry N, Costa-Nunes CM, Cagnon L, Gannon PO, Abed-Maillard S, Baumgaertner P, Murray T, Letovanec I, Lazor R, Bouchaab H, Rufer N, Romano E, Michielin O, Speiser DE
Pulmonary sarcoid-like granulomatosis after multiple vaccinations of a long-term surviving patient with metastatic melanoma.
Cancer immunology research 2014 Dec;2;1148-53 — 2014 Dec — 1148-53