The Drug-Induced Respiratory Disease Website and App

Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IX.a

Diaphragm/inspiratory muscle weakness/paralysis (w/wo ARF)

Publications

Lin X, Guan W, Li B, Deng H, Chen Y, Yang Y, Qiu G, Xie X, Zhou C

A case report and literature review on respiratory failure with immune checkpoint inhibitors: a life-threatening adverse event.

Immunopharmacology and immunotoxicology. 2023;45(6):780-787

Kadota H, Gono T, Shirai Y, Okazaki Y, Takeno M, Kuwana M

Immune Checkpoint Inhibitor-Induced Myositis: a Case Report and Literature Review.

Current rheumatology reports. 2019;21(4):10