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The Drug-Induced Respiratory Disease Website and App

Sirolimus

I - Interstitial/parenchymal lung disease

I.a

Pneumonitis (interstitial lung disease/ILD)

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

I.e

Organizing pneumonia pattern (an area or areas of consolidation on imaging)

I.f

Acute fibrinous organizing pneumonia (AFOP)

I.m

Diffuse alveolar damage (DAD) (see alsoo under IIb and XVf)

I.n

ILD with a granulomatous component

I.o

Pulmonary alveolar proteinosis (PAP)

XLI - Pulmonary edema - Acute lung injury - ARDS

XLI.e

ARDS - Acute lung injury

XLII - Pulmonary/alveolar./airway hemorrhage/bleeding

XLII.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

XLIII - Airway involvement

XLIII.g

Airway hyperresponsiveness

XLIII.ab

Cough (lone)

XLIII.aj

Bronchial stump dehiscence

XLIV - Central-large-upper airway (incl. pharyngeal-nasal) involvement

XLIV.a

Angioedema (may cause UAO, asphyxia and death)

XLV - Pleural and/or pericardial involvement

XLV.m

Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)

XLVI - Pulmonary vasculopathy

XLVI.a

Pulmonary embolism - Venous thrombosis/thromboembolism

XLVI.d

Pulmonary vasculitis or capillaritis

XLVI.f

Hemolytic and uremic syndrome (HUS). See also under Xaf

XLIX - Systemic/Distant conditions, syndromes and reactions

XLIX.c

Capillary leak syndrome (CLS)

LI - Cardiovascular involvement / toxicity

LI.c

Pericardial effusion (w/wo tamponade)

LV - Imaging

LV.b

Imaging: Ground-glass opacities (GGO) / shadowing

LV.k

Imaging: An area or areas of consolidation

LVII - Cytological, biochemical features of/in BAL, pleural fluid or FNA

LVII.a

BAL: An excess proportion of lymphocytes

LVIII - Pathology

LVIII.d

Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)

LVIII.e

Path: Acute fibrinous organizing pneumonia (AFOP-pattern) (see also If)

LVIII.f

Path: ILD with a granulomatous component (see also Im)

LVIII.g

Path: Pulmonary necrotizing granuloma or granulomas

LVIII.k

Path: Desquamative interstitial pneumonia (DIP-pattern)

LVIII.n

Path: Pulmonary alveolar proteinosis pattern (PAP pattern)

LVIII.o

Path: Diffuse alveolar damage (DAD-pattern) (see also IL)

LVIII.r

Path: Alveolar hemorrhage (see also IIIa)

LVIII.aj

Path: Lymphoid hyperplasia (including nodular- or a lymphocytic interstitial pneumonia pattern)

LVIII.ay

Path: Pulmonary vasculitis other than capillaritis

LIX - Infections & related conditions

LIX.b

Opportunistic pulmonary/systemic infections

LIX.e

Pneumocystis jiroveci pneumonia