The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LVIII.f

Path: ILD with a granulomatous component (see also Im)

Publications

Roberts RJ, Wells AC, Unitt E, Griffiths M, Tasker AD, Allison ME, Bradley JA, Watson CJ

Sirolimus-induced pneumonitis following liver transplantation.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2007 Jun;13;853-6 — 2007 Jun — 853-6

Sola E, Lopez V, Burgos D, Cabello M, Gutierrez C, Martin A, Peña M, Gonzalez-Molina M

Pulmonary toxicity associated with sirolimus treatment in kidney transplantation.

Transplantation proceedings 2006 Oct;38;2438-40 — 2006 Oct — 2438-40

Howard L, Gopalan D, Griffiths M, Mahadeva R

Sirolimus-induced pulmonary hypersensitivity associated with a CD4 T-cell infiltrate.

Chest 2006 Jun;129;1718-21 — 2006 Jun — 1718-21

Chhajed PN, Dickenmann M, Bubendorf L, Mayr M, Steiger J, Tamm M

Patterns of pulmonary complications associated with sirolimus.

Respiration; international review of thoracic diseases 2006;73;367-74 — 2006 — 367-74

Avitzur Y, Jimenez-Rivera C, Fecteau A, Jones N, Ngan BY, Ng VL

Interstitial granulomatous pneumonitis associated with sirolimus in a child after liver transplantation.

Journal of pediatric gastroenterology and nutrition 2003 Jul;37;91-4 — 2003 Jul — 91-4

Morelon E, Stern M, Israël-Biet D, Correas JM, Danel C, Mamzer-Bruneel MF, Peraldi MN, Kreis H

Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patients.

Transplantation 2001 Sep 15;72;787-90 — 2001 Sep 15 — 787-90