The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (ILD), acute and/or severe (may produce the ARDS pattern)

May cause an ARDS picture

Publications

Tejwani V, Panchabhai TS, Kotloff RM, Mehta AC

Complications of Lung Transplantation: A Roentgenographic Perspective.

Chest. 2016;149(6):1535-45

Wang WL, Yu LX

Acute respiratory distress attributed to sirolimus in solid organ transplant recipients.

The American journal of emergency medicine. 2015;33(1):124.e1-4

Roberts RJ, Wells AC, Unitt E, Griffiths M, Tasker AD, Allison ME, Bradley JA, Watson CJ

Sirolimus-induced pneumonitis following liver transplantation.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 2007;13(6):853-6

Das BB, Shoemaker L, Subramanian S, Johnsrude C, Recto M, Austin EH

Acute sirolimus pulmonary toxicity in an infant heart transplant recipient: case report and literature review.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2007;26(3):296-8

Garrean S, Massad MG, Tshibaka M, Hanhan Z, Caines AE, Benedetti E

Sirolimus-associated interstitial pneumonitis in solid organ transplant recipients.

Clinical transplantation. 2005;19(5):698-703

Manito N, Kaplinsky EJ, Bernat R, Roca J, Castells E, Serrano T, Esplugas E

Fatal interstitial pneumonitis associated with sirolimus therapy in a heart transplant recipient.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2004;23(6):780-2