The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LVIII.n

Path: Pulmonary alveolar proteinosis pattern (PAP pattern)

Publications

Narotzky S, Kennedy CC, Maldonado F

An unusual cause of respiratory failure in a 25-year-old heart and lung transplant recipient.

Chest 2015 May;147;e185-e188 — 2015 May — e185-e188

Kirby S, Satoskar A, Brodsky S, Pope-Harman A, Nunley D, Hitchcock C, Pelletier R, Ross P, Nadasdy T, Shilo K

Histological spectrum of pulmonary manifestations in kidney transplant recipients on sirolimus inclusive immunosuppressive regimens.

Diagnostic pathology 2012 Mar 14;7;25 — 2012 Mar 14 — 25

Kadikoy H, Paolini M, Achkar K, Suki W, Gaber AO, Anwar N, Jeroudi A, Barrios R, Abdellatif A

Pulmonary alveolar proteinosis in a kidney transplant: a rare complication of sirolimus.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2010 Aug;25;2795-8 — 2010 Aug — 2795-8