The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.o

Pulmonary alveolar proteinosis (PAP)

Publications

Marchasson L, Dutilh J, Jouneau S, Bironneau V

Sirolimus-Induced Pulmonary Alveolar Proteinosis in the Context of Hematopoietic Stem Cells Transplant Rejection: A Case Report.

Transplantation proceedings 2022 Jan 06;; — 2022 Jan 06

Wang S, Lee E, Lau R, Wang T

Sirolimus-induced secondary pulmonary alveolar proteinosis.

Respiratory medicine case reports 2022;35;101566 — 2022 — 101566

Narotzky S, Kennedy CC, Maldonado F

An unusual cause of respiratory failure in a 25-year-old heart and lung transplant recipient.

Chest 2015 May;147;e185-e188 — 2015 May — e185-e188

Kirby S, Satoskar A, Brodsky S, Pope-Harman A, Nunley D, Hitchcock C, Pelletier R, Ross P, Nadasdy T, Shilo K

Histological spectrum of pulmonary manifestations in kidney transplant recipients on sirolimus inclusive immunosuppressive regimens.

Diagnostic pathology 2012 Mar 14;7;25 — 2012 Mar 14 — 25

Kadikoy H, Paolini M, Achkar K, Suki W, Gaber AO, Anwar N, Jeroudi A, Barrios R, Abdellatif A

Pulmonary alveolar proteinosis in a kidney transplant: a rare complication of sirolimus.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2010 Aug;25;2795-8 — 2010 Aug — 2795-8

Pérez MJ, Martín RO, García DM, Rey JM, de la Cruz Lombardo J, Rodrigo López JM

Interstitial pneumonitis associated with sirolimus in liver transplantation: a case report.

Transplantation proceedings 2007 Dec;39;3498-9 — 2007 Dec — 3498-9

Pedroso SL, Martins LS, Sousa S, Reis A, Dias L, Henriques AC, Sarmento AM, Cabrita A

Pulmonary alveolar proteinosis: a rare pulmonary toxicity of sirolimus.

Transplant international : official journal of the European Society for Organ Transplantation 2007 Mar;20;291-6 — 2007 Mar — 291-6