MTOR inhibitors
Mammalian-TOR inhibitors. Reviews and management at PMID 22689175, 23852656, 24517115, 25580277, 26836903
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The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
I - Interstitial/parenchymal lung disease
I.a
Pneumonitis (ILD), acute and/or severe (may cause ARDS)
I.b
Pneumonitis (interstitial lung disease/ILD)
I.d
Organizing pneumonia pattern (an area or areas of consolidation on imaging)
I.l
Diffuse alveolar damage (DAD) (see alsoo under IIb and XVf)
I.m
ILD with a granulomatous component
I.p
Fatal pneumonitis (ILD)