The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.d

Organizing pneumonia pattern (an area or areas of consolidation on imaging)

Publications

Howard L, Gopalan D, Griffiths M, Mahadeva R

Sirolimus-induced pulmonary hypersensitivity associated with a CD4 T-cell infiltrate.

Chest. 2006;129(6):1718-21

Chhajed PN, Dickenmann M, Bubendorf L, Mayr M, Steiger J, Tamm M

Patterns of pulmonary complications associated with sirolimus.

Respiration; international review of thoracic diseases. 2006;73(3):367-74

Lindenfeld JA, Simon SF, Zamora MR, Cool CD, Wolfel EE, Lowes BD, Ireland N, Keller K, Frisk R, Stepien L, Cleveland JC Jr, Zolty R

BOOP is common in cardiac transplant recipients switched from a calcineurin inhibitor to sirolimus.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2005;5(6):1392-6

Pham PT, Pham PC, Danovitch GM, Ross DJ, Gritsch HA, Kendrick EA, Singer J, Shah T, Wilkinson AH

Sirolimus-associated pulmonary toxicity.

Transplantation. 2004;77(8):1215-20

McWilliams TJ, Levvey BJ, Russell PA, Milne DG, Snell GI

Interstitial pneumonitis associated with sirolimus: a dilemma for lung transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2003;22(2):210-3

Morelon E, Stern M, Israël-Biet D, Correas JM, Danel C, Mamzer-Bruneel MF, Peraldi MN, Kreis H

Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patients.

Transplantation. 2001;72(5):787-90

Singer SJ, Tiernan R, Sullivan EJ

Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipients.

The New England journal of medicine. 2000;343(24):1815-6