The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLII.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Arya P, Prickett KK, Raol N, Briones M, Evans S

Sirolimus-induced pulmonary hemorrhage of an infant with massive cervicofacial lymphatic malformation: A case report.

International journal of pediatric otorhinolaryngology 2023 Jan;164;111404 — 2023 Jan — 111404

Serifoglu I, Er Dedekarginoglu B, Ayvazoglu Soy EH, Ulubay G, Haberal M

Causes of Hemoptysis in Renal Transplant Patients.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 2018 Mar;16 Suppl 1;70-74 — 2018 Mar — 70-74

Kirby S, Satoskar A, Brodsky S, Pope-Harman A, Nunley D, Hitchcock C, Pelletier R, Ross P, Nadasdy T, Shilo K

Histological spectrum of pulmonary manifestations in kidney transplant recipients on sirolimus inclusive immunosuppressive regimens.

Diagnostic pathology 2012 Mar 14;7;25 — 2012 Mar 14 — 25

Patel AV, Hahn T, Bogner PN, Loud PA, Brown K, Paplham P, Syta M, Battiwalla M, McCarthy PL

Fatal diffuse alveolar hemorrhage associated with sirolimus after allogeneic hematopoietic cell transplantation.

Bone marrow transplantation 2010 Aug;45;1363-4 — 2010 Aug — 1363-4

Rabe C, Appenrodt B, Hoff C, Ewig S, Klehr HU, Sauerbruch T, Nickenig G, Tasci S

Severe respiratory failure due to diffuse alveolar hemorrhage: clinical characteristics and outcome of intensive care.

Journal of critical care 2010 Jun;25;230-5 — 2010 Jun — 230-5

Hashemi-Sadraei N, Sadrpour S, Baram D, Miller F, Nord EP

Sirolimus-associated diffuse alveolar hemorrhage in a renal transplant recipient on long-term anticoagulation.

Clinical nephrology 2007 Oct;68;238-44 — 2007 Oct — 238-44

Khalife WI, Kogoj P, Kar B

Sirolimus-induced alveolar hemorrhage.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2007 Jun;26;652-7 — 2007 Jun — 652-7

Damas C, Oliveira A, Morais A

[Lung toxicity induced by rapamycin].

Revista portuguesa de pneumologia 2006 Nov-Dec;12;715-24 — 2006 Nov-Dec — 715-24

Champion L, Stern M, Israël-Biet D, Mamzer-Bruneel MF, Peraldi MN, Kreis H, Porcher R, Morelon E

Brief communication: sirolimus-associated pneumonitis: 24 cases in renal transplant recipients.

Annals of internal medicine 2006 Apr 04;144;505-9 — 2006 Apr 04 — 505-9

Chhajed PN, Dickenmann M, Bubendorf L, Mayr M, Steiger J, Tamm M

Patterns of pulmonary complications associated with sirolimus.

Respiration; international review of thoracic diseases 2006;73;367-74 — 2006 — 367-74

Pham PT, Pham PC, Danovitch GM, Ross DJ, Gritsch HA, Kendrick EA, Singer J, Shah T, Wilkinson AH

Sirolimus-associated pulmonary toxicity.

Transplantation 2004 Apr 27;77;1215-20 — 2004 Apr 27 — 1215-20

Vlahakis NE, Rickman OB, Morgenthaler T

Sirolimus-associated diffuse alveolar hemorrhage.

Mayo Clinic proceedings 2004 Apr;79;541-5 — 2004 Apr — 541-5

Morelon E, Stern M, Israël-Biet D, Correas JM, Danel C, Mamzer-Bruneel MF, Peraldi MN, Kreis H

Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patients.

Transplantation 2001 Sep 15;72;787-90 — 2001 Sep 15 — 787-90