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The Drug-Induced Respiratory Disease Website and App

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I - Interstitial/parenchymal lung disease

Diffuse pulmonary calcification (calciphylaxis)

Last update 11/09/2026

(Fr: calcification(s) pulmonaire(s) diffuse(s)). PMID 23323114, 24529738, 29719190) is a rare pattern that can be diagnosed on imaging, including HRCT and bone scan, in the form of multiple pulmonary opacities that are 99Tc-avid. Opacities have a predilection for the lung apices or they can be diffuse to the lung and distant organs. A few cases were documented on pathology.

Causative drugs

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Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

Calcium replacement therapy
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Hemodialysis - Chronic renal replacement therapy
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Status post-kidney transplantation
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Vitamin D
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Warfarin
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