Philippe Camus, M.D.
Dijon, France
Fluid silicone is used by cosmetic surgeons or by illegal 'lay' surgeons, or by incompetent and unscrupulous operators (PMID; 16738424) for the purpose of body augmentation mammaplasty (then in the breasts) or in the context of transsexualism. The compound may cause severe or fatal silicone embolism syndrome with DAH, ARDS and/or MODS
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)
Path: Diffuse alveolar damage (DAD-pattern) (see also IL)
Path: Alveolar hemorrhage (see also IIIa)
Path: Pulmonary fibrosis (not otherwise specified or unclassifiable)
Path: Silicone droplets/vacuoles in lung tissue, pulmonary vasculature, or lymph nodes
Path: Silicone pulmonary embolism
Path: Siliconoma
