The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VI.m

Silicone pulmonary embolism (SE) - SE syndrome

Presentations include pulmonary infiltrates, ALI/ARDS, DAH, and CNS involvement

Publications

Nebel A, Veit F, Weber A, Martz W, Lasczkowski G, Dettmeyer R

Liquid silicone embolism syndrome (SES) in lungs and liver - A case report.

Forensic science international. 2021;325:110872

Lyapichev K, Chinea FM, Poveda J, Pereda J, Bejarano PA, Garcia-Buitrago MT

Pulmonary Empty Spaces: Silicone Embolism-A Decade of Increased Incidence and Its Histological Diagnosis.

Case reports in pathology. 2016;2016:3741291

Adegunsoye AO, Matchett S, Valentino DJ

A 20-year-old woman with rapidly progressive dyspnea and diffuse pulmonary infiltrates.

Respiratory medicine case reports. 2012;5:34-6

Bach AG, Restrepo CS, Abbas J, Villanueva A, Lorenzo Dus MJ, Schöpf R, Imanaka H, Lehmkuhl L, Tsang FH, Saad FF, Lau E, Rubio Alvarez J, Battal B, Behrmann C, Spielmann RP, Surov A

Imaging of nonthrombotic pulmonary embolism: biological materials, nonbiological materials, and foreign bodies.

European journal of radiology. 2013;82(3):e120-41

Alva RV, Yacoub WJ

A young woman with pulmonary hemorrhage and hypoxic respiratory failure.

Chest. 2010;137(2):484-7

Restrepo CS, Artunduaga M, Carrillo JA, Rivera AL, Ojeda P, Martinez-Jimenez S, Manzano AC, Rossi SE

Silicone pulmonary embolism: report of 10 cases and review of the literature.

Journal of computer assisted tomography. 2009;33(2):233-7

Price EA, Schueler H, Perper JA

Massive systemic silicone embolism: a case report and review of literature.

The American journal of forensic medicine and pathology. 2006;27(2):97-102

Schmid A, Tzur A, Leshko L, Krieger BP

Silicone embolism syndrome: a case report, review of the literature, and comparison with fat embolism syndrome.

Chest. 2005;127(6):2276-81

Chung KY, Kim SH, Kwon IH, Choi YS, Noh TW, Kwon TJ, Shin DH

Clinicopathologic review of pulmonary silicone embolism with special emphasis on the resultant histologic diversity in the lung--a review of five cases.

Yonsei medical journal. 2002;43(2):152-9

Duong T, Schonfeld AJ, Yungbluth M, Slotten R

Acute pneumopathy in a nonsurgical transsexual.

Chest. 1998;113(4):1127-9

Ellenbogen R, Rubin L

Injectable fluid silicone therapy. Human morbidity and mortality.

JAMA. 1975;234(3):308-9