The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLVI.m

Silicone pulmonary embolism (SE) - SE syndrome

Presentations include pulmonary infiltrates, ALI/ARDS, DAH, and CNS involvement

Publications

Nebel A, Veit F, Weber A, Martz W, Lasczkowski G, Dettmeyer R

Liquid silicone embolism syndrome (SES) in lungs and liver - A case report.

Forensic science international 2021 Jun 13;325;110872 — 2021 Jun 13 — 110872

Lyapichev K, Chinea FM, Poveda J, Pereda J, Bejarano PA, Garcia-Buitrago MT

Pulmonary Empty Spaces: Silicone Embolism-A Decade of Increased Incidence and Its Histological Diagnosis.

Case reports in pathology 2016;2016;3741291 — 2016 — 3741291

Adegunsoye AO, Matchett S, Valentino DJ

A 20-year-old woman with rapidly progressive dyspnea and diffuse pulmonary infiltrates.

Respiratory medicine case reports 2012;5;34-6 — 2012 — 34-6

Bach AG, Restrepo CS, Abbas J, Villanueva A, Lorenzo Dus MJ, Schöpf R, Imanaka H, Lehmkuhl L, Tsang FH, Saad FF, Lau E, Rubio Alvarez J, Battal B, Behrmann C, Spielmann RP, Surov A

Imaging of nonthrombotic pulmonary embolism: biological materials, nonbiological materials, and foreign bodies.

European journal of radiology 2013 Mar;82;e120-41 — 2013 Mar — e120-41

Alva RV, Yacoub WJ

A young woman with pulmonary hemorrhage and hypoxic respiratory failure.

Chest 2010 Feb;137;484-7 — 2010 Feb — 484-7

Restrepo CS, Artunduaga M, Carrillo JA, Rivera AL, Ojeda P, Martinez-Jimenez S, Manzano AC, Rossi SE

Silicone pulmonary embolism: report of 10 cases and review of the literature.

Journal of computer assisted tomography 2009 Mar-Apr;33;233-7 — 2009 Mar-Apr — 233-7

Price EA, Schueler H, Perper JA

Massive systemic silicone embolism: a case report and review of literature.

The American journal of forensic medicine and pathology 2006 Jun;27;97-102 — 2006 Jun — 97-102

Schmid A, Tzur A, Leshko L, Krieger BP

Silicone embolism syndrome: a case report, review of the literature, and comparison with fat embolism syndrome.

Chest 2005 Jun;127;2276-81 — 2005 Jun — 2276-81

Chung KY, Kim SH, Kwon IH, Choi YS, Noh TW, Kwon TJ, Shin DH

Clinicopathologic review of pulmonary silicone embolism with special emphasis on the resultant histologic diversity in the lung--a review of five cases.

Yonsei medical journal 2002 Apr;43;152-9 — 2002 Apr — 152-9

Duong T, Schonfeld AJ, Yungbluth M, Slotten R

Acute pneumopathy in a nonsurgical transsexual.

Chest 1998 Apr;113;1127-9 — 1998 Apr — 1127-9

Ellenbogen R, Rubin L

Injectable fluid silicone therapy. Human morbidity and mortality.

JAMA 1975 Oct 20;234;308-9 — 1975 Oct 20 — 308-9