The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XV.bn

Path: Silicone droplets/vacuoles in lung tissue, pulmonary vasculature, or lymph nodes

Publications

Azeem A, Khuwaja S, Parthvi R, Persaud T

Pulmonary fibrosis and embolism secondary to silicon implant leak.

BMJ case reports. 2019;12(6)

Lyapichev K, Chinea FM, Poveda J, Pereda J, Bejarano PA, Garcia-Buitrago MT

Pulmonary Empty Spaces: Silicone Embolism-A Decade of Increased Incidence and Its Histological Diagnosis.

Case reports in pathology. 2016;2016:3741291

D'hulst L, Nicolaij D, Beels L, Gheysens O, Alaerts H, Van de Wiele C, Maes A

False-Positive Axillary Lymph Nodes Due to Silicone Adenitis on (18)F-FDG PET/CT in an Oncological Setting.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2016;11(6):e73-5

Essenmacher AC, Astani SA

Respiratory Disease following Illicit Injection of Silicone: A Case Report.

Case reports in medicine. 2013;2013:743842

Lewin-Smith M, Kalasinsky V, Shilo K, Tomashefski J, Cropp A

Detection of silicone in lung tissue.

Archives of pathology & laboratory medicine. 2012;136(10):1179-80; author reply 1180

Paredes Vila S, Gonzalez Barcala FJ, Suarez Antelo J, Moldes Rodriguez M, Abdulkader Nallib I, Valdes Cuadrado L

Pneumonitis caused by silicone gel following breast implant rupture.

Irish journal of medical science. 2010;179(1):141-5

Parikh R, Karim K, Parikh N, Han P, Daoko J, Shamoon FE

Case report and literature review: acute pneumonitis and alveolar hemorrhage after subcutaneous injection of liquid silicone.

Annals of clinical and laboratory science. 2008;38(4):380-5

Price EA, Schueler H, Perper JA

Massive systemic silicone embolism: a case report and review of literature.

The American journal of forensic medicine and pathology. 2006;27(2):97-102

Gurvits GE

Silicone pneumonitis after a cosmetic augmentation procedure.

The New England journal of medicine. 2006;354(2):211-2

Schmid A, Tzur A, Leshko L, Krieger BP

Silicone embolism syndrome: a case report, review of the literature, and comparison with fat embolism syndrome.

Chest. 2005;127(6):2276-81

Kim CH, Chung DH, Yoo CG, Lee CT, Han SK, Shim YS, Kim YW

A case of acute pneumonitis induced by injection of silicone for colpoplasty.

Respiration; international review of thoracic diseases. 2003;70(1):104-6

Chung KY, Kim SH, Kwon IH, Choi YS, Noh TW, Kwon TJ, Shin DH

Clinicopathologic review of pulmonary silicone embolism with special emphasis on the resultant histologic diversity in the lung--a review of five cases.

Yonsei medical journal. 2002;43(2):152-9

Duong T, Schonfeld AJ, Yungbluth M, Slotten R

Acute pneumopathy in a nonsurgical transsexual.

Chest. 1998;113(4):1127-9

Chastre J, Basset F, Viau F, Dournovo P, Bouchama A, Akesbi A, Gibert C

Acute pneumonitis after subcutaneous injections of silicone in transsexual men.

The New England journal of medicine. 1983;308(13):764-7

Ellenbogen R, Rubin L

Injectable fluid silicone therapy. Human morbidity and mortality.

JAMA. 1975;234(3):308-9