The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

III.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Eckle VS, Lambiris N, Grund D, Vogtmann M, Ruwwe-Glösenkamp C, Uhrig A, Suttorp N, Witzenrath M, Müller-Redetzky H

[Acute Respiratory Failure after Silicone Injection].

Pneumologie (Stuttgart, Germany). 2019;73(10):582-585

Blanco J, Gaines S, Arshad J, Sheele JM

Silicone pneumonitis, diffuse alveolar hemorrhage and acute respiratory distress syndrome from gluteal silicone injections.

The American journal of emergency medicine. 2018;36(12):2340.e3-2340.e4

Mongero LB, Brodie D, Cunningham J, Ventetuolo C, Kim H, Sylvan E, Bacchetta MD

Extracorporeal membrane oxygenation for diffuse alveolar hemorrhage and severe hypoxemic respiratory failure from silicone embolism.

Perfusion. 2010;25(4):249-52; discussion 253-4

Alva RV, Yacoub WJ

A young woman with pulmonary hemorrhage and hypoxic respiratory failure.

Chest. 2010;137(2):484-7

Zamora AC, Collard HR, Barrera L, Mendoza F, Webb WR, Carrillo G

Silicone injection causing acute pneumonitis: a case series.

Lung. 2009;187(4):241-4

Restrepo CS, Artunduaga M, Carrillo JA, Rivera AL, Ojeda P, Martinez-Jimenez S, Manzano AC, Rossi SE

Silicone pulmonary embolism: report of 10 cases and review of the literature.

Journal of computer assisted tomography. 2009;33(2):233-7

Parikh R, Karim K, Parikh N, Han P, Daoko J, Shamoon FE

Case report and literature review: acute pneumonitis and alveolar hemorrhage after subcutaneous injection of liquid silicone.

Annals of clinical and laboratory science. 2008;38(4):380-5

Schmid A, Tzur A, Leshko L, Krieger BP

Silicone embolism syndrome: a case report, review of the literature, and comparison with fat embolism syndrome.

Chest. 2005;127(6):2276-81

Chung KY, Kim SH, Kwon IH, Choi YS, Noh TW, Kwon TJ, Shin DH

Clinicopathologic review of pulmonary silicone embolism with special emphasis on the resultant histologic diversity in the lung--a review of five cases.

Yonsei medical journal. 2002;43(2):152-9

Lai YF, Chao TY, Wong SL

Acute pneumonitis after subcutaneous injections of silicone for augmentation mammaplasty.

Chest. 1994;106(4):1152-5