The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLII.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Eckle VS, Lambiris N, Grund D, Vogtmann M, Ruwwe-Glösenkamp C, Uhrig A, Suttorp N, Witzenrath M, Müller-Redetzky H

[Acute Respiratory Failure after Silicone Injection].

Pneumologie (Stuttgart, Germany) 2019 Oct;73;582-585 — 2019 Oct — 582-585

Blanco J, Gaines S, Arshad J, Sheele JM

Silicone pneumonitis, diffuse alveolar hemorrhage and acute respiratory distress syndrome from gluteal silicone injections.

The American journal of emergency medicine 2018 Dec;36;2340.e3-2340.e4 — 2018 Dec — 2340.e3-2340.e4

Mongero LB, Brodie D, Cunningham J, Ventetuolo C, Kim H, Sylvan E, Bacchetta MD

Extracorporeal membrane oxygenation for diffuse alveolar hemorrhage and severe hypoxemic respiratory failure from silicone embolism.

Perfusion 2010 Jul;25;249-52; discussion 253-4 — 2010 Jul — 249-52; discussion 253-4

Alva RV, Yacoub WJ

A young woman with pulmonary hemorrhage and hypoxic respiratory failure.

Chest 2010 Feb;137;484-7 — 2010 Feb — 484-7

Zamora AC, Collard HR, Barrera L, Mendoza F, Webb WR, Carrillo G

Silicone injection causing acute pneumonitis: a case series.

Lung 2009 Aug;187;241-4 — 2009 Aug — 241-4

Restrepo CS, Artunduaga M, Carrillo JA, Rivera AL, Ojeda P, Martinez-Jimenez S, Manzano AC, Rossi SE

Silicone pulmonary embolism: report of 10 cases and review of the literature.

Journal of computer assisted tomography 2009 Mar-Apr;33;233-7 — 2009 Mar-Apr — 233-7

Parikh R, Karim K, Parikh N, Han P, Daoko J, Shamoon FE

Case report and literature review: acute pneumonitis and alveolar hemorrhage after subcutaneous injection of liquid silicone.

Annals of clinical and laboratory science 2008;38;380-5 — 2008 — 380-5

Schmid A, Tzur A, Leshko L, Krieger BP

Silicone embolism syndrome: a case report, review of the literature, and comparison with fat embolism syndrome.

Chest 2005 Jun;127;2276-81 — 2005 Jun — 2276-81

Chung KY, Kim SH, Kwon IH, Choi YS, Noh TW, Kwon TJ, Shin DH

Clinicopathologic review of pulmonary silicone embolism with special emphasis on the resultant histologic diversity in the lung--a review of five cases.

Yonsei medical journal 2002 Apr;43;152-9 — 2002 Apr — 152-9

Lai YF, Chao TY, Wong SL

Acute pneumonitis after subcutaneous injections of silicone for augmentation mammaplasty.

Chest 1994 Oct;106;1152-5 — 1994 Oct — 1152-5