The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LVIII.r

Path: Alveolar hemorrhage (see also IIIa)

Publications

Essenmacher AC, Astani SA

Respiratory Disease following Illicit Injection of Silicone: A Case Report.

Case reports in medicine 2013;2013;743842 — 2013 — 743842

Parikh R, Karim K, Parikh N, Han P, Daoko J, Shamoon FE

Case report and literature review: acute pneumonitis and alveolar hemorrhage after subcutaneous injection of liquid silicone.

Annals of clinical and laboratory science 2008;38;380-5 — 2008 — 380-5

Schmid A, Tzur A, Leshko L, Krieger BP

Silicone embolism syndrome: a case report, review of the literature, and comparison with fat embolism syndrome.

Chest 2005 Jun;127;2276-81 — 2005 Jun — 2276-81