The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.e

ARDS - Acute lung injury

Results in this setting from silicone embolism. See under that pattern and also under DAH

Publications

Madan N, Khan U, Martins A, Andries G, Matthews J, Patel V, Visveswaran G

Recurrent Silicone Embolism Syndrome requiring VA ECMO.

Respiratory medicine case reports 2022;36;101576 — 2022 — 101576

Blanco J, Gaines S, Arshad J, Sheele JM

Silicone pneumonitis, diffuse alveolar hemorrhage and acute respiratory distress syndrome from gluteal silicone injections.

The American journal of emergency medicine 2018 Dec;36;2340.e3-2340.e4 — 2018 Dec — 2340.e3-2340.e4

Soeroso NN, Rhinsilva E, Soeroso L

Acute pneumonitis following breast silicone liquid injection.

Respirology case reports 2018 Aug;6;e00335 — 2018 Aug — e00335

Adegunsoye AO, Matchett S, Valentino DJ

A 20-year-old woman with rapidly progressive dyspnea and diffuse pulmonary infiltrates.

Respiratory medicine case reports 2012;5;34-6 — 2012 — 34-6

Alva RV, Yacoub WJ

A young woman with pulmonary hemorrhage and hypoxic respiratory failure.

Chest 2010 Feb;137;484-7 — 2010 Feb — 484-7

Bartsich S, Wu JK

Silicon emboli syndrome: a sequela of clandestine liquid silicone injections. A case report and review of the literature.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS 2010 Jan;63;e1-3 — 2010 Jan — e1-3

Zamora AC, Collard HR, Barrera L, Mendoza F, Webb WR, Carrillo G

Silicone injection causing acute pneumonitis: a case series.

Lung 2009 Aug;187;241-4 — 2009 Aug — 241-4

Clark RF, Cantrell FL, Pacal A, Chen W, Betten DP

Subcutaneous silicone injection leading to multi-system organ failure.

Clinical toxicology (Philadelphia, Pa.) 2008 Nov;46;834-7 — 2008 Nov — 834-7

Gurvits GE

Silicone pneumonitis after a cosmetic augmentation procedure.

The New England journal of medicine 2006 Jan 12;354;211-2 — 2006 Jan 12 — 211-2

Chung KY, Kim SH, Kwon IH, Choi YS, Noh TW, Kwon TJ, Shin DH

Clinicopathologic review of pulmonary silicone embolism with special emphasis on the resultant histologic diversity in the lung--a review of five cases.

Yonsei medical journal 2002 Apr;43;152-9 — 2002 Apr — 152-9

Duong T, Schonfeld AJ, Yungbluth M, Slotten R

Acute pneumopathy in a nonsurgical transsexual.

Chest 1998 Apr;113;1127-9 — 1998 Apr — 1127-9

Chastre J, Basset F, Viau F, Dournovo P, Bouchama A, Akesbi A, Gibert C

Acute pneumonitis after subcutaneous injections of silicone in transsexual men.

The New England journal of medicine 1983 Mar 31;308;764-7 — 1983 Mar 31 — 764-7

Chastre J, Brun P, Soler P, Basset F, Trouillet JL, Fagon JY, Gibert C, Hance AJ

Acute and latent pneumonitis after subcutaneous injections of silicone in transsexual men.

The American review of respiratory disease 1987 Jan;135;236-40 — 1987 Jan — 236-40