The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.b

ARDS - Acute lung injury

Results in this setting from silicone embolism. See under that pattern and also under DAH

Publications

Madan N, Khan U, Martins A, Andries G, Matthews J, Patel V, Visveswaran G

Recurrent Silicone Embolism Syndrome requiring VA ECMO.

Respiratory medicine case reports. 2022;36:101576

Blanco J, Gaines S, Arshad J, Sheele JM

Silicone pneumonitis, diffuse alveolar hemorrhage and acute respiratory distress syndrome from gluteal silicone injections.

The American journal of emergency medicine. 2018;36(12):2340.e3-2340.e4

Soeroso NN, Rhinsilva E, Soeroso L

Acute pneumonitis following breast silicone liquid injection.

Respirology case reports. 2018;6(6):e00335

Adegunsoye AO, Matchett S, Valentino DJ

A 20-year-old woman with rapidly progressive dyspnea and diffuse pulmonary infiltrates.

Respiratory medicine case reports. 2012;5:34-6

Alva RV, Yacoub WJ

A young woman with pulmonary hemorrhage and hypoxic respiratory failure.

Chest. 2010;137(2):484-7

Bartsich S, Wu JK

Silicon emboli syndrome: a sequela of clandestine liquid silicone injections. A case report and review of the literature.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS. 2010;63(1):e1-3

Zamora AC, Collard HR, Barrera L, Mendoza F, Webb WR, Carrillo G

Silicone injection causing acute pneumonitis: a case series.

Lung. 2009;187(4):241-4

Clark RF, Cantrell FL, Pacal A, Chen W, Betten DP

Subcutaneous silicone injection leading to multi-system organ failure.

Clinical toxicology (Philadelphia, Pa.). 2008;46(9):834-7

Gurvits GE

Silicone pneumonitis after a cosmetic augmentation procedure.

The New England journal of medicine. 2006;354(2):211-2

Chung KY, Kim SH, Kwon IH, Choi YS, Noh TW, Kwon TJ, Shin DH

Clinicopathologic review of pulmonary silicone embolism with special emphasis on the resultant histologic diversity in the lung--a review of five cases.

Yonsei medical journal. 2002;43(2):152-9

Duong T, Schonfeld AJ, Yungbluth M, Slotten R

Acute pneumopathy in a nonsurgical transsexual.

Chest. 1998;113(4):1127-9

Chastre J, Basset F, Viau F, Dournovo P, Bouchama A, Akesbi A, Gibert C

Acute pneumonitis after subcutaneous injections of silicone in transsexual men.

The New England journal of medicine. 1983;308(13):764-7

Chastre J, Brun P, Soler P, Basset F, Trouillet JL, Fagon JY, Gibert C, Hance AJ

Acute and latent pneumonitis after subcutaneous injections of silicone in transsexual men.

The American review of respiratory disease. 1987;135(1):236-40