The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

Publications

Azeem A, Khuwaja S, Parthvi R, Persaud T

Pulmonary fibrosis and embolism secondary to silicon implant leak.

BMJ case reports 2019 Jun 14;12; — 2019 Jun 14

Soeroso NN, Rhinsilva E, Soeroso L

Acute pneumonitis following breast silicone liquid injection.

Respirology case reports 2018 Aug;6;e00335 — 2018 Aug — e00335

Essenmacher AC, Astani SA

Respiratory Disease following Illicit Injection of Silicone: A Case Report.

Case reports in medicine 2013;2013;743842 — 2013 — 743842