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The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
XLIII - Airway involvement
XLIV - Central-large-upper airway (incl. pharyngeal-nasal) involvement
XLIX - Systemic/Distant conditions, syndromes and reactions
L - Miscellaneous
LIX - Infections & related conditions
LIX.a
Respiratory tract infection incl. pneumonia
LIX.b
Opportunistic pulmonary/systemic infections
LIX.c
Aspergillosis, pulmonary (invasive, allergic [ABPA], or mycetoma)
LIX.e
Pneumocystis jiroveci pneumonia
LIX.g
Tuberculosis (pulmonary, pulmonary, extrapulmonary or disseminated). Reactivation or de novo
LIX.h
Nontuberculous pulmonary mycobacterial infection/superinfection
LIX.k
Bacterial (incl. Pseudomonas) airway colonization
LIX.m
Fungal airway infection
LIX.w
Aspergillus airway colonization/infection