The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Laryngeal disorder-Laryngeal nerve palsy (dysphonia, hoarseness)
Publications
Tracheobronchopathy From Inhaled Corticosteroids.
Chest. 2017;152(6):1296-1305
Voice evaluation in asthma patients using inhaled corticosteroids.
Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat. 2016;26(2):101-8
Dysphonia associated with the use of inhaled corticosteroids.
Current opinion in otolaryngology & head and neck surgery. 2015;23(3):255-9
Practical considerations for dysphonia caused by inhaled corticosteroids.
Mayo Clinic proceedings. 2012;87(9):901-4
Corticosteroid-induced laryngeal disorders in asthma.
Medical science monitor : international medical journal of experimental and clinical research. 2006;12(8):CR351-4
Local oropharyngeal side effects of inhaled corticosteroids in patients with asthma.
Allergy. 2006;61(5):518-26
Administration of cortisone by the aerosol method in the treatment of bronchial asthma.
The New England journal of medicine. 1951;245(8):293-4
Dysphonia caused by inhaled steroids: recognition of a characteristic laryngeal abnormality.
Thorax. 1983;38(11):813-21