The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LIX.g

Tuberculosis (pulmonary, pulmonary, extrapulmonary or disseminated). Reactivation or de novo

Publications

Lee CM, Heo J, Han SS, Moon KW, Lee SH, Kim YJ, Lee SJ, Kwon JW

Inhaled Corticosteroid-Related Tuberculosis in the Real World Among Patients with Asthma and COPD: A 10-Year Nationwide Population-Based Study.

The journal of allergy and clinical immunology. In practice 2019 Apr;7;1197-1206.e3 — 2019 Apr — 1197-1206.e3

Chung WS, Chen YF, Hsu JC, Yang WT, Chen SC, Chiang JY

Inhaled corticosteroids and the increased risk of pulmonary tuberculosis: a population-based case-control study.

International journal of clinical practice 2014 Oct;68;1193-9 — 2014 Oct — 1193-9

Dong YH, Chang CH, Wu FL, Shen LJ, Calverley PMA, Löfdahl CG, Lai MS, Mahler DA

Use of inhaled corticosteroids in patients with COPD and the risk of TB and influenza: A systematic review and meta-analysis of randomized controlled trials. a systematic review and meta-analysis of randomized controlled trials.

Chest 2014 Jun;145;1286-1297 — 2014 Jun — 1286-1297

Lee CH, Kim K, Hyun MK, Jang EJ, Lee NR, Yim JJ

Use of inhaled corticosteroids and the risk of tuberculosis.

Thorax 2013 Dec;68;1105-13 — 2013 Dec — 1105-13

Kim JH, Park JS, Kim KH, Jeong HC, Kim EK, Lee JH

Inhaled corticosteroid is associated with an increased risk of TB in patients with COPD.

Chest 2013 Apr;143;1018-1024 — 2013 Apr — 1018-1024

Brassard P, Suissa S, Kezouh A, Ernst P

Inhaled corticosteroids and risk of tuberculosis in patients with respiratory diseases.

American journal of respiratory and critical care medicine 2011 Mar 01;183;675-8 — 2011 Mar 01 — 675-8

Shu CC, Wu HD, Yu MC, Wang JT, Lee CH, Wang HC, Wang JY, Lee LN, Yu CJ, Yang PC,

Use of high-dose inhaled corticosteroids is associated with pulmonary tuberculosis in patients with chronic obstructive pulmonary disease.

Medicine 2010 Jan;89;53-61 — 2010 Jan — 53-61