The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

L.v

Adrenal suppression

Publications

Lapi F, Kezouh A, Suissa S, Ernst P

The use of inhaled corticosteroids and the risk of adrenal insufficiency.

The European respiratory journal 2013 Jul;42;79-86 — 2013 Jul — 79-86

de Vries TW, de Langen-Wouterse JJ, van Puijenbroek E, Duiverman EJ, de Jong-Van den Berg LT

Reported adverse drug reactions during the use of inhaled steroids in children with asthma in the Netherlands.

European journal of clinical pharmacology 2006 May;62;343-6 — 2006 May — 343-6

Eid N, Morton R, Olds B, Clark P, Sheikh S, Looney S

Decreased morning serum cortisol levels in children with asthma treated with inhaled fluticasone propionate.

Pediatrics 2002 Feb;109;217-21 — 2002 Feb — 217-21

Brus R

Effects of high-dose inhaled corticosteroids on plasma cortisol concentrations in healthy adults.

Archives of internal medicine 1999 Sep 13;159;1903-8 — 1999 Sep 13 — 1903-8