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XLIX.ac

XLIX - Systemic/Distant conditions, syndromes and reactions

Propofol infusion syndrome (PRIS)

Last update 17/06/2026

Presentation includes (PMID 17567345) acute refractory bradycardia leading to asystole, metabolic acidosis (base deficit >10 mmol.l-1), rhabdomyolysis, hyperlipidaemia, enlarged or fatty liver and in some, ARDS may develop

Causative drugs

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Propofol