The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.a

Bronchospasm - Wheezing - Asthma

Publications

Nishiyama T

Propofol results in higher incidence of bronchoconstriction in allergic patients.

Medical archives (Sarajevo, Bosnia and Herzegovina). 2013;67(3):168-70

Rüggeberg A, Breckwoldt J

[Live-threatening bronchospasm during anesthesia induction : when pure routine becomes a nightmare].

Der Anaesthesist. 2011;60(10):937-41

Fontaine M, Dubost J, Bienvenu F, Ferrenq Dubost R, Proton G, Piriou V

[Severe bronchospasm using Diprivan® in a patient allergic to peanut and birch].

Annales francaises d'anesthesie et de reanimation. 2011;30(2):147-9

Nishiyama T, Hanaoka K

Propofol-induced bronchoconstriction: two case reports.

Anesthesia and analgesia. 2001;93(3):645-6