The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

L.e

Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea

Publications

Kitterer D, Schwab M, Alscher MD, Braun N, Latus J

Drug-induced acid-base disorders.

Pediatric nephrology (Berlin, Germany) 2015 Sep;30;1407-23 — 2015 Sep — 1407-23

Choi YJ, Kim MC, Lim YJ, Yoon SZ, Yoon SM, Yoon HR

Propofol infusion associated metabolic acidosis in patients undergoing neurosurgical anesthesia: a retrospective study.

Journal of Korean Neurosurgical Society 2014 Aug;56;135-40 — 2014 Aug — 135-40

Romero P C, Morales R M, Donaire R L, Llanos V O, Cornejo R R, Gálvez A R, Castro O J

[Severe lactic acidosis caused by propofol infusion: report of one case].

Revista medica de Chile 2008 Jan;136;88-92 — 2008 Jan — 88-92

Fudickar A, Bein B, Tonner PH

Propofol infusion syndrome in anaesthesia and intensive care medicine.

Current opinion in anaesthesiology 2006 Aug;19;404-10 — 2006 Aug — 404-10

Cray SH, Robinson BH, Cox PN

Lactic acidemia and bradyarrhythmia in a child sedated with propofol.

Critical care medicine 1998 Dec;26;2087-92 — 1998 Dec — 2087-92

Marinella MA

Lactic acidosis associated with propofol.

Chest 1996 Jan;109;292 — 1996 Jan — 292