The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XI.d

Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea

Publications

Kitterer D, Schwab M, Alscher MD, Braun N, Latus J

Drug-induced acid-base disorders.

Pediatric nephrology (Berlin, Germany). 2015;30(9):1407-23

Choi YJ, Kim MC, Lim YJ, Yoon SZ, Yoon SM, Yoon HR

Propofol infusion associated metabolic acidosis in patients undergoing neurosurgical anesthesia: a retrospective study.

Journal of Korean Neurosurgical Society. 2014;56(2):135-40

Romero P C, Morales R M, Donaire R L, Llanos V O, Cornejo R R, Gálvez A R, Castro O J

[Severe lactic acidosis caused by propofol infusion: report of one case].

Revista medica de Chile. 2008;136(1):88-92

Fudickar A, Bein B, Tonner PH

Propofol infusion syndrome in anaesthesia and intensive care medicine.

Current opinion in anaesthesiology. 2006;19(4):404-10

Cray SH, Robinson BH, Cox PN

Lactic acidemia and bradyarrhythmia in a child sedated with propofol.

Critical care medicine. 1998;26(12):2087-92

Marinella MA

Lactic acidosis associated with propofol.

Chest. 1996;109(1):292