Propofol can produce the Propofol Infusion Syndrome (PRIS), which may include rhabdomyolysis, arrhythmias, respiratory failure, metabolic acidosis, cardiovascular collapse, cardiac arrest and pulmonary edema. Propofol may cause addiction. Health care workers are exposed, due to easy access to the drug (PMID: 19567716, 24314538)
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
