Lomustine (CCNU)
See under 'nitrosoureas' and all other nitrosoureas (suffix '-mustine') which may produce similar reactions as a class effect
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The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
I - Interstitial/parenchymal lung disease
I.a
Pneumonitis (ILD), acute and/or severe (may produce the ARDS pattern)
I.g
Pulmonary fibrosis
I.h
Subclinical pulmonary infiltrates/ILD
I.l
Diffuse alveolar damage (DAD) (see alsoo under IIb and XVf)
I.v
Abnormal lung function/pulmonary physiology (PFTs) without necessarily imaging or clinical evidence