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The Drug-Induced Respiratory Disease Website and App

Mitomycin C

Intra-vesical or -peritoneal mitomycin can also induce ILD/DAD (PMID 20130385, 19757670, 17434283)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I - Interstitial/parenchymal lung disease

I.a

Pneumonitis (ILD), acute and/or severe (may produce the ARDS pattern)
I.b

Pneumonitis (interstitial lung disease/ILD)
I.g

Pulmonary fibrosis
I.h

Subclinical pulmonary infiltrates/ILD
I.l

Diffuse alveolar damage (DAD) (see alsoo under IIb and XVf)
I.v

Abnormal lung function/pulmonary physiology (PFTs) without necessarily imaging or clinical evidence
I.w

Rapidly progressive ILD/pulmonary fibrosis (Hamman-Rich syndrome)

II - Pulmonary edema - Acute lung injury - ARDS

II.a

Pulmonary edema, noncardiogenic (NCPE)
II.b

ARDS - Acute lung injury
II.c

ARDS and the hemolytic-uremic syndrome (HUS)

III - Pulmonary/alveolar/airway hemorrhage/bleeding

III.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

VI - Pulmonary vasculopathy

VI.b

Pulmonary arterial hypertension
VI.c

Pulmonary veno-occlusive disease
VI.f

Hemolytic and uremic syndrome (HUS). See also under Xaf
VI.p

Angiomatoid pulmonary vasculopathy

VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement

VIII.c

Upper airway obstruction other than angioedema or hematoma

X - Systemic/Distant conditions, syndromes and reactions

X.k

Sarcoid-like granulomatosis (endo-/extrathoracic)

XV - Pathology

XV.a

Path: NSIP-cellular pattern (see also Ia, Ib)
XV.i

Path: Pneumocyte atypia (reactive epithelial cells) (a.k.a. the "Napoleon Hat" sign)
XV.ak

Path: Pulmonary veno-occlusive disease (PVOD)