The Drug-Induced Respiratory Disease Website and App

Mitomycin C

Intra-vesical or -peritoneal mitomycin can also induce ILD/DAD (PMID 20130385, 19757670, 17434283)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I - Interstitial/parenchymal lung disease

I.a

Pneumonitis (interstitial lung disease/ILD)

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

I.g

Pulmonary fibrosis

I.i

Subclinical pulmonary infiltrates/ILD

I.m

Diffuse alveolar damage (DAD) (see alsoo under IIb and XVf)

I.w

Abnormal lung function/pulmonary physiology (PFTs) without necessarily imaging or clinical evidence

I.x

Rapidly progressive ILD/pulmonary fibrosis (Hamman-Rich syndrome)

XLI - Pulmonary edema - Acute lung injury - ARDS

XLI.a

Pulmonary edema, noncardiogenic (NCPE)

XLI.e

ARDS - Acute lung injury

XLI.f

ARDS and the hemolytic-uremic syndrome (HUS)

XLII - Pulmonary/alveolar./airway hemorrhage/bleeding

XLII.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

XLIV - Central-large-upper airway (incl. pharyngeal-nasal) involvement

XLIV.c

Upper airway obstruction other than angioedema or hematoma

XLVI - Pulmonary vasculopathy

XLVI.b

Pulmonary arterial hypertension

XLVI.c

Pulmonary veno-occlusive disease

XLVI.f

Hemolytic and uremic syndrome (HUS). See also under Xaf

XLVI.u

Angiomatoid pulmonary vasculopathy

XLIX - Systemic/Distant conditions, syndromes and reactions

XLIX.m

Sarcoid-like granulomatosis (endo-/extrathoracic)

LVIII - Pathology

LVIII.a

Path: NSIP-cellular pattern (see also Ia, Ib)

LVIII.q

Path: Pneumocyte atypia (reactive epithelial cells) (a.k.a. the "Napoleon Hat" sign)

LVIII.bd

Path: Pulmonary veno-occlusive disease (PVOD)